Researches and scholars still don't all agree on the answer. There are several studies which indicate a correlation between creativity and mental illness, however. These are pretty intriguing to say the very least.
Some medications can contribute to the problem. Aspirin is a particularly bad trigger, though some studies indicate that low dose (under 81 mgs) may not be a problem. Black tea and alcohol use can also be a trigger.
The greatest advantage of natural products is that they are completely harmless. Unlike pharmaceutical drugs they have no side effects on human effects on human body leaving a beneficial impact on overall health.