The technology of biologics drug


Posted June 23, 2021 by Bonnibelle

All kinds of carbon-based organisms with medical research value are used as raw materials, manufactured by traditional technology or modern biotechnology

 
All kinds of carbon-based organisms with medical research value are used as raw materials, manufactured by traditional technology or modern biotechnology, and are used to prevent (health care), treatment and diagnosis of various physiological symptoms of the human body. They are collectively referred to as biological agents.

"Biological agents" in the pharmaceutical industry specifically refers to "immune biological agents", which refers to the processing of microorganisms (bacteria, rickettsia, viruses, etc.) and their metabolites, effective antigen components, animal toxins, human or animal blood or tissues, etc. It is used as a biological product for the prevention, treatment, and diagnosis of corresponding infectious diseases or other related diseases.

Medical biologics
The production of medical biological preparations, such as vaccines, broad-spectrum biological preparations, etc., has a series of characteristics in addition to the requirements for the production of all drugs. For example, there must be the first stage in production---cultivation of microorganisms, viruses, living cells, and subsequent processing of biological materials, as well as the characteristics of cleanliness, passivation, extraction, freezing, and freeze-drying. For example, adalimumab needs aseptic conditions when completing many production processes and meets the requirements of micro-contamination control.

Health Biological Agents
Hariyao calcium gluconate oral solution, calcium lactate, calcium gluconate, zinc lactate, vitamin D.
Ricafor antibacterial spray, the main ingredients are lactic acid, lactic acid bacteria, lactic acid bacteria and so on. The main function is antibacterial and antipruritic, nursing for reproductive infection diseases.

Technology

Recombinant DNA Technology
DNA recombination, recombination is the recombination of genetic material, which is generally accompanied by the process of transferring genetic material. Use artificial methods to connect specific genes (donors) and vector DNA, then transfer them to another biological host cell (recipient), and integrate with the host cell DNA. When the host cell proliferates, the target gene It also proliferates, thereby changing certain genetic characteristics of the host cell and expressing the protein encoded by the target gene. It can also be said that asexual splicing propagation method transmits genetic information.

Cell and protoplast fusion technology
Cell fusion or cell hybridization refers to the process by which eukaryotic cells are mediated and cultured to merge two or more cells into a binuclear or multinucleated cell. Artificial cell fusion began in the 1950s. As a new technology from the 1960s to the 1970s, it has developed very fast and has a wide range of applications. In addition to the fusion between cells of the same type, distant cells between species can also fuse. Cells are different from tissues, and heterogeneous and heterogeneous cells are not excluded. This is true for animal cells and the same is true for plant cells. Cell fusion can not only be used in the basic theoretical research of biology, but also has important application value in production practice, in the preparation of monoclonal antibodies, nucleocytoplasmic relationship, somatic cell heredity and development, the cultivation of new varieties, and the immune function. Significant achievements have been made in the treatment of diseases, improvement of traits, and research on latent viruses.

Protoplast Fusion Technology
Protoplast is the general term for living substances in cells. Protoplast fusion has great significance in theory and practice, and has broad application prospects in plant genetic engineering and breeding research. It is one of the ways to obtain homologous and heterologous polyploid plants. It can not only overcome the barriers to sexual incompatibility of distant hybridization, but also overcome the traditional troubles of inducing polyploid plants through sexual hybridization. Distant genes from wild species are introduced into cultivated species. Protoplast fusion technology is expected to become one of the powerful tools for crop improvement.

Plant detoxification and rapid propagation technology
Plant detoxification technology is to use methods such as high temperature treatment and shoot tip tissue culture to remove viruses from plants, and cultivate virus-free animal and plant strains under ultra-clean and sterile conditions for vegetative reproduction, rapid breeding and production Produce virus-free seedlings and seed potatoes, suitable for field growth.
Rapid clonal propagation technology, also known as micro-propagation technology, refers to the technology of in vitro aseptic culture through plant embryos, tissues or organs to quickly obtain a large number of test tube bacteria. It has opened up a new way to maintain the biological species and to efficiently and rapidly multiply the offspring of improved species.
Mass culture technology of animal and plant cells
Cell culture (cellculture): refers to a method in which cells are separated from small pieces of tissue from a living body and cultured under certain conditions to enable them to continue to survive, grow, and proliferate. Advantages: Observe the law of cell life activities in vitro, not affected by the internal environment, and can artificially change the conditions to further observe the changes in physiological functions.

Animal embryo engineering technology
Embryo engineering is mainly to carry out some kind of artificial engineering technology operation on the mammalian embryo, and then let it continue to develop, and obtain the new technology of adult animals that people need. In fact, it is the expansion and extension of animal cell engineering. As early as 1891, Hepp of the University of Cambridge in the United Kingdom successfully carried out the first successful experiment of transplanting fertilized eggs on rabbits. By the 1930s, this technology had gained more and more obvious benefits in animal husbandry. In the 1970s, companies specializing in fertilized egg transplantation emerged. Fertilized egg transplantation of higher animals is also called "livestock embryo transfer". It is a technology that takes the early embryos of excellent breeding animals from the body of the donor mothers and moves them into the oviduct or uterus of the recipient mothers, and reproduces the excellent animals by "pregnancy with the abdomen".

Modern microbial fermentation technology
Bread, steamed bread, yogurt, wine, soy sauce, vinegar, sauce, kimchi, sauerkraut, fermented bean curd, glutinous rice, cheese, etc., are directly produced by microbial fermentation. Since the establishment of the antibiotic industry in modern fermentation engineering, independent fermentation industrial systems such as amino acids, citric acid, enzyme preparations, steroid hormones, vitamins, single-cell proteins, and microbial pesticides have also emerged.

Protein engineering technology
The so-called protein engineering is the use of genetic engineering methods, including site-directed mutations and gene expression of genes to modify proteins, in order to obtain protein molecules with more perfect properties and functions. Modification and transformation of enzymes involved in important life activities in animals and plants is an important goal for the future development of protein engineering. One day, people will be able to design and control the regulatory proteins that interact with DNA through protein engineering. By then, they will be able to artificially control heredity and transform life.

About us
BOC Sciences not only provides the synthesis of small molecules and biopolymers, but also contributes to functionalization or activation of compounds ready for cross-linking with pre-activated small molecules. These small molecules are either supplied by customers or prepared internally. Here are some our products: conjugated protein, antibody conjugation, adc technologies and antibody oligo conjugation, etc.
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Issued By https://bioconjugation.bocsci.com/
Country United States
Categories Biotech
Last Updated June 23, 2021