Huateng Pharma can supply high quality of 2,4-Diamino-6-chloropyrimidine (CAS NO.156-83-2), an intermediate of Minoxidil for the treatment of hair loss with commercial production.

Biopharma PEG innovatively uses plant sterols as starting materials to prepare plant-derived cholesterol (CAS NO.: 57-88-5) through biological fermentation and green synthesis, eliminating the generation and carrying of viruses from the source.

As of January 1, 2023, global vaccine development includes a total of 966 vaccine candidates, of which 23% (220) are traditional inactivated or attenuated vaccines.

Diabetes is a chronic disease that affects more than 540 million people worldwide and is one of the leading causes of death and disability worldwide.

Biopharma PEG offers a wide range of PEG products for click chemistry reactions. It supplies PEG products & reagents functionalized with azide, alkyne, DBCO and other cyclooctyne. Below is a part of PEG for click chemistry reactions.

Now, let’s make a comparison of CDK4/6 inhibitors.

In summary, many preclinical studies have innovated to improve therapeutic efficacy or overcome the shortcomings of existing ADCs, thus inspiring the field of antibody drug conjugates and expanding the forms of development.

ADCs combine the high specificity of monoclonal antibody drugs with the high activity of small molecule cytotoxic drugs, which can improve the targeting of antitumor drugs and reduce the probability of toxic and side effects.

This article introduced the development trends and potential challenges of PROTACs.

GLP-1 agonists and SGLT-2 inhibitors in combination with or without metformin have also been recommended by multiple guidelines as appropriate initial treatment for type 2 diabetes patients.

The team finally identified PRZ-18002 as a candidate compound, which can selectively induce p-p38 degradation without interfering with similar proteins and unphosphorylated p38.

Currently, 15 ADC drugs have been approved worldwide, including three for breast cancer: T-DM1 and T-DXd, which target HER2, and sacituzumab govitecan, which targets Trop2.

Biopharma PEG specializes exclusively in the development and manufacturing of high-quality polyethylene glycol (PEG) products and derivatives, and related custom synthesis and PEGylation services.

Tetrahydrocurcumin is an antioxidant and skin-whitening ingredient. Tetrahydrocurcumin has a good therapeutic effect on metabolic syndrome, obesity type 2 diabetes, hypertension, insulin resistance syndrome and other related diseases.

Huateng Pharma develops Fluralaner (CAS NO.864731-61-3) and can supply it in lager quantities. We have our own factory with first-class production equipment and quality management system.

Biochempeg is dedicated to provide a chemical synthesis and high-quality PEG linkers. We are committed to promoting the progress of your ADC discovery and development projects.

Biopharma PEG provides high-quality activated multi-arm PEG derivatives including 4-arm and 8-arm PEG products which can be crosslinked into degradable PEG hydrogels.

Carfilzomib, a proteasome inhibitor, is indicated for the treatment of patients with multiple myeloma. Huateng Pharma develops intermediates of Carfilzomib for multiple myeloma.

Nine types of conjugated drugs were reviewed from their characteristics, development progress and future development trend.

This article introduces the potential applications of mRNA technology, ophthalmology could be a breakthrough.

At present, the pathogenesis of AD remains unclear. β-Amyloid deposition and tau hyperphosphorylation are widely recognized as neurobiological mechanisms of AD pathogenesis.

PROTAC is a heterobifunctional molecule with one end connected to a ligand that binds the target protein, one end to an E3 ubiquitin ligase, and a suitable Linker in the middle.

Currently, targeted protein degradators are mainly divided into two types: small molecular "molecular glue" and biffunctional molecular degradators (PROTAC).

Pembrolizumab is a class of immunotherapy drugs called immune checkpoint inhibitors (ICIs), while ramucirumab is a vascular endothelial growth factor receptor 2 (VEGFR-2) inhibitor, a class of drugs that block the enzyme drug.

PEG is a polyether compound derived from petroleum with many applications, from industrial manufacturing to medicine. PEG has wide variety of applications depending on the length of the polymer chain and the molecular weight of the final polymer.

Canagliflozin is a medication used to treat type 2 diabetes. It is a third-line medication to be tried after metformin, a first-line medication for type 2 diabetes. It is used together with exercise and diet. It is not recommended in type 1 diabetes.

PEG linkers are widely used in biological and medical research, such as antibody-drug conjugates, nanoparticle drug delivery, biotinylation, PEGylation protein drugs and small molecule drugs, etc.

Ensitrelvir (code name S-217622, Xocova), is a new inhibitor of the SARS-CoV-2 major protease (Mpro), also known as 3C-like protease, has been shown to reduce the viral load and help alleviate the severity of SARS-CoV-2 in infected hamsters.

On February 16, 2022, the data on Paxlovid previously published by Pfizer and submitted to the FDA were published in the New England Journal of Medicine (NEJM).

The nanoparticles, known as SNAs, house immune targets, globular DNA that can enter and stimulate immune cells with extremely high efficiency. SNAs have been tested in more than 60 cell types.

On February 16, 2022, the data on Paxlovid previously published by Pfizer and submitted to the FDA were published in the New England Journal of Medicine (NEJM).

Among adults with overweight or obesity, once-weekly subcutaneous semaglutide plus counseling for diet and physical activity results in significantly greater weight loss at 68 weeks than once-daily subcutaneous liraglutide

Orlistat is a lipase inhibitor used in the treatment of obesity that works by inhibiting fat-metabolizing enzymes.

3D printing (3DP) technology has been repurposed to apply to pharmaceutical development, in recent years it has been used to produce tablets of personalized dosage and combine several prescriptions into one tablet.

Eating at least two serves of fruit daily has been linked with 36 percent lower odds of developing type 2 diabetes, a new Edith Cowan University (ECU) study has found.

Antibody-Drug Conjugates (ADC) is a type of anticancer drug that links a drug to cancer-targeting antibodies. The antibody detects tumor-specific proteins expressed on cancer cells and directs the cytotoxic anticancer drug towards the cancer cell.

Case reports of younger COVID-19 patients developing Parkinson’s disease within weeks of contracting the virus led researchers to investigate a possible link between the two conditions.

Sacituzumab govitecan shows promise in treating the most aggressive type of breast cancer-Metastatic triple-negative breast cancer.

Dolutegravir (DTG), sold under the brand name Tivicay, is an antiretroviral medication used, together with other medication, to treat HIV/AIDS.

These types of jabs are new but researchers have been working for decades to try to figure out how to use messenger RNA for other vaccinations and to treat illnesses from AIDS to cancer.

This is part of a broader piece of research, which aims to look at whether prescribing patterns of these drugs in people with diabetes have changed over time and whether these drugs affect the risk of complications in people with diabetes.

Antibody-drug conjugate (ADC), one of a rapidly growing class of anticancer agents, has curative effect on cell surface protein in Neuroblastoma.

Several observational studies found a strong correlation between vitamin D deficiency and COVID-19.

On Aug 12, the FDA amended the emergency use authorizations (EUAs) for both the Pfizer-BioNTech & the Moderna COVID-19 Vaccine to allow for the use of an additional dose in certain immunocompromised individuals.

New research led by investigators at Massachusetts General Hospital (MGH) uncovers some of the key factors that are needed for survival of immune cells in the battle against cancer.

In a recent study published in Nature Communications Biology, researchers identified a way to interfere with a sneaky mechanism the virus uses to prevent a response from an infected person's immune system.

Unlike common diseases such as colds and coughs, cancer is a more significant disease with a high mortality rate. Globally, cancer causes the second largest number of deaths after cardiovascular disease.

Lipid nanoparticles have been developed as vehicles for small molecule delivery by the nanomedicine and materials communities and are now a key component of COVID-19 mRNA vaccines.

Researchers at the Francis Crick Institute have identified a protein that helps tumors evade the immune system and, in certain types of cancers, is linked to a poorer chance of survival.

Immunotherapy, treatment of cancer with substances that strengthen the body’s natural immune response, is the most prominent topic within melanoma research, accounting for 4.9 percent of papers published between 2013 and 2018.