Expanding clusters of the new coronavirus were eyed warily Wednesday as the outbreak upended daily life and reshaped everything from the United States presidential race to Pope Francis' travel.

In the US, the caseload passed 1,000, and outbreaks on both sides of the country were stirring alarm, while in Europe, an increasingly locked-down Italy counted more than 10,000 infections and recorded soaring deaths among its aging population.

"Right now, the epicenter - the new China - is Europe," said Robert Redfield, the head of the US Centers for Disease Control and Prevention.

Rome's usual boisterous hum was reduced to a whisper as Italy's 62 million people were told to mostly stay home. Though shops, cafes and restaurants remained open, police around the country were enforcing rules that customers stay 1 meter (3 feet) apart and certain businesses shutter by 6 p.m.

Authorities said 631 people have died of COVID-19 in Italy, with an increase of 168 fatalities recorded Tuesday. The health crisis was dealing a serious blow to the country's economy - the third-largest of the 19 countries using the euro - and threatened instability worldwide.

Markets across Asia dropped Wednesday despite Wall Street's gains a day earlier. Investors seemed encouraged by promises by US President Donald Trump of a relief package to cushion economic pain from the outbreak. Governments around Asia and elsewhere have also announced billions of dollars in stimulus funds, including packages revealed in Japan on Tuesday and Australia on Wednesday.

"Investors are still worried that those fiscal stimulus packages may not be able to contain the virus outbreak as well as to mitigate the impact on the economy," said Louis Wong of Philip Capital Management.