Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen work by preventing the cyclooxygenase-2 (COX-2) enzyme from producing prostaglandins – a class of molecules that induce inflammation, pain and fever. However, COX-2 inhibitors were reported to raise the risk of heart attack and stroke in patients taking them. While looking for alternatives to the production of safer painkillers, researchers discovered that inhibiting macrophage specific prostaglandin E synthase-1 enzyme resulted in a reduction in pain along with cardio vascular benefits in mice.



Conducting research to support new treatments for pain and heart disease requires high quality reagents and cell lines. For years, GenScript has been delivering high quality, soluble recombinant proteins and stable cell lines to researchers around the world. Using its custom, proprietary technologies, state-of-the-art facilities, PhD-level technical support and rich scientific expertise, GenScript will be a reliable partner for all your protein production projects.