Oligonucleotides are short DNA or RNA molecules and have specific sequence of nucleotide residue, which makes an entire molecule. Oligonucleotides readily bind in specific sequencing manner to their respective DNA-RNA oligonucleotide to form duplex chain. Oligonucleotides are chemically synthesized molecular chains with phosphoramidite components of natural or chemically modified nucleosides and have wide range of applications in generic testing, research, and forensic.

The global oligonucleotide synthesis market is estimated to be valued at US$ 2,874.1 Million in 2020 and is expected to exhibit a CAGR of 11.3% during the forecast period (2020-2027).

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Increasing research and development activities in the field of genomics and genetics is expected to propel the market growth during the forecast period

Research institutes and diagnostic centers have shifted their focus on genomics and genetics due, which has increased demand for high quality synthesized oligonucleotides in the market over the past few years. For instance, in July 2020, researchers of Rosalind Franklin University of Medicine and Science initiated a new therapeutic approach for treating Batten disease, a fatal neurodegenerative disease in children with the help of antisense oligonucleotides. These factors are expected to drive the global oligonucleotide synthesis market growth over the forecast period.

Expansion of manufacturing facilities by market players is expected to drive the market growth during the forecast period

Biotechnological companies are focusing on expanding their manufacturing facilities due to increasing demand for oligonucleotides from pharmaceutical companies. For instance, in March 2020, STA pharmaceuticals, a subsidiary of WuXi AppTech, announced inauguration of its large scale oligonucleotide active pharmaceutical ingredient manufacturing facility in China.

Global Oligonucleotide Synthesis Market – Impact of Coronavirus (COVID-19) Pandemic

The coronavirus disease (COVID-19) outbreak was first reported on December 31, 2019, in Wuhan, China. The World Health Organization declared COVID-19 as pandemic on March 11, 2020.

According to the Coronavirus Disease (COVID-19) Weekly Epidemiological Update by the World Health Organization, over 61.8 million cases and 1.4 million deaths due to coronavirus disease (COVID-19) were reported up till November 29, 2020 across the globe.
In order to deal with the COVID-19 pandemic, market players and government authorities are collaborating, in order to explore the oligonucleotide platform for the development of COVID-19 treatment. For instance, on April 28, 2020, Sarepta Therapeutics, Inc., and the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), a department of defense’s lead laboratory for medical biological defense research entered into a cooperative research and development agreement (CRADA) to identify antisense oligonucleotides against SARS-CoV-2 for the potential treatment of COVID-19.

Global Oligonucleotide Synthesis Market: Restraints

Natural oligonucleotides are composed of ribose or deoxyribose sugar phosphate as a base, which are quickly degraded in the body by nucleus. Moreover in generic testing, oligo-degradation can affect cell growth and cell proliferation. Furthermore, low quality of microarray generated oligonucleotide sequence is a major challenge in adopting microarray technology for oligonucleotide synthesis. These factors are expected to restrain the global oligonucleotide synthesis market growth.

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Key Players

Major players operating in the global oligonucleotide synthesis market include Thermo Fisher Scientific, Sigma-Aldrich Corporation, GE Healthcare, Integrated DNA Technologies, Inc., TriLink BioTechnologies, Inc, BioAutomation Corporation, Twist Bioscience, Shanghai SynTheAll Pharmaceutical Co., CUSABIO Technology LLC, Synbio Technologies, GENEWIZ, Eurofins Scientific, Agilent Technologies, Kaneka Eurogentec S.A., and LGC, Biosearch Technologies

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