Introduction of depression: depression is a disease caused by variety of comprehensive factors. The symptoms often relapse and tend to be chronic, even hinder the daily lives of individuals. With the increasingly fierce competition of society, life and work pressure increases so that depression has become a very common mental illness in modern society. According to the World Health Organization (who) of United Nations, depression will become the second vital disease causing human death and disability to 2020.
Model advantage: at present, there are few studies on the depression models of non-human primates in domestic and foreign countries. The main tools used are rodent models, such as large and small mice. However, the clinical efficacy of the antidepressant drugs shows clearly that these models have irreparable defects. They can only partially simulate the core symptoms of human depression. There is no animal model which can completely simulate all the performances of depression, and rodents and human beings are different. Compared to rodents, the neurobiology characteristics of non-human primates are very similar with human beings, and the most important thing is, after training, non-human primates can accomplish a specific task related memory for evaluation of cognitive and emotional behavior changes. What’s more, they have similar social environment and rich patterns of behavior with the humans. They are the most ideal experimental animal models to study nosogenesis of depression, because the results of the research are easy to translate directly into clinical applications. We have made some achievements on the study of depression model.

The brain hippocampus of depression monkey, we can use fluorescent two-dimensional electrophoresis for proteomic analysis;
Mass spectrometry analysis of 8 differential expression proteins, its content of those proteins decrease significantly in depression monkeys;
In the smaller molecular weight place of same isoelectric point, through mass spectrometry analysis there identify two phosphatidylethanolamine binding protein 1 protein spots, also called PEBP1 protein spots.
In further study, in hippocampus of spontaneous depression monkey, PEBP1 expression increases and its phosphorylation level decreases.
At present, PEBP1 function abnormalities are known related with a variety of diseases, including cancer, Alzheimer's disease and pancreatitis. There are few related researches in terms of depression, and not inconclusive results.
In future, we will continue to study the role that PEBP1 plays on spontaneous depression monkey on its occurrence and development, study the possibility that PEBP1 may treat depression targets. PEBP1 has important scientific significance and potential application prospect to guide the anti depression drug development.

About the author:
Creative Animodel expertizes in developing and running non-human primate (NHP) animal models to test drug candidates and medical devices for their pharmacological effects and biocompatible repairs, as well as conducting adjacent studies in PK/PD, in vivo pharmacology and preliminary toxicology.

Website: http://www.creative-animodel.com