Recombinant proteins have immense potential in cancer therapy research and development. For instance, growth factors, immune checkpoint, and cell damage & oxidative stress proteins (preclinical stage) are utilized from recombinant proteins category for cancer therapy research. Increased understanding of oncogenic signaling pathways and proteins involved in the same has increased the targeting ways, wherein, recombinant proteins such as immune checkpoint, growth factors, and antibodies are used. These proteins are used extensively by researchers to research cancer signaling pathways and functioning. The Global Recombinant Protein Market was valued at US$ 347.2 million in 2016 and is expected to witness a robust CAGR of 6.2% over the forecast period (2017–2025).

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Recombinant immune checkpoint such as PD-1/PD-L1 Inhibitor 1 and PD-1/PD-L1 Inhibitor 2, which directly targets programmed death-1 (PD-1) and programmed death ligand-1 and 2 (PD-L1) are used for research purposes. Moreover, proteins such as CD226, CD40 Ligand/TRAP, and Human CellExp CTLA4/CD152 are extensively used in cancer therapies research.

Market Dynamics

Increasing demand for recombinant proteins for basic research has supported growth of recombinant protein market. Manufacturers are involved in recombinant protein product innovation in order to improve research outcomes along with improvements in other areas such as expression techniques, and protein purification techniques, which compliments growth of the recombinant protein market. The market is expected to gain significant growth, owing increasing adoption of biologics and biosimilars, which will in turn impact recombinant proteins market, along with rising prevalence of chronic diseases such as cancer. Furthermore, availability of wide number of innovative recombinant proteins from various sources such as human and animal, lack of suitable alternative for basic protein related therapies research, and increasing demand for biological products is expected to fuel growth of the market.

Technological advancement in production of recombinant protein is expected to fuel growth of the recombinant protein market

Advancement in technologies in various areas associated with or facilitating recombinant protein production have supported growth of recombinant protein market. For instance, development of alternative expression technologies such as mammalian cell expression, baculovirus expression, and E.coli expression, development of alternative cell lines, and enhanced cell culture systems have simplified and optimized recombinant protein processes. Furthermore, advanced chromatography protein purification methods such as FPLC and HPLC help in providing highly purified clinical grade recombinant proteins. Clustered regularly interspaced short palindromic repeats (CRISPR) technique is a genome editing technique used to target destruction in human cells and can improve recombinant protein production.

Moreover, advancements in bioreactor systems have improved the product’s output within shorter time. According to National Centre for Biotechnology Information (NCBI), in 2014, about 65.6% of clinical scale manufacturers and 42% of commercial manufacturers adopted single use bioreactor for improvement in their bioprocessing.

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Some major players operating in the recombinant protein market include Crown Bioscience, Inc., ProSpec Tany TechnoGene, Ltd., BPS Bioscience, Inc., Sigma Aldrich Company Ltd., Novoprotein Scientific, PeproTech, Inc., Feldan Bio, Inc., BioVision, Inc., HumanZyme, Inc., and GenScript Biotech Corporation.

Increasing research & development expenditure on biologic drugs is expected to boost demand for recombinant proteins for research purposes

Biopharmaceutical organizations are focusing on research and development of novel biosimilars for life threatening diseases such as cardiovascular diseases, cancer, metabolic disorders such as diabetes, and certain rare conditions such as hemophilia. According to Pharmaceutical Research and Manufacturers of America (PhRMA), 2016, member companies invested around US$ 58.8 billion in research and development in 2015, of which, majority was by all biopharmaceutical companies in the U.S. Rare disease medical space holds potential as there is relatively low competition. This is owing to less understanding of the disease progression pathways and entities. Therefore, companies could focus on R&D for development of biologics and subsequently biosimilars in this space.

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