The primary cause of the disease is atherosclerosis or the buildup of fatty deposits called plaque in the arteries. Other risk factors for the disease include hypercholesterolemia, obesity, smoking, hypertension and diabetes. Diabetes is a significant risk factor because it is often linked with severe PADs. The most common symptoms of CLI are the ischemic rest pain — extreme pain or hard to heal sores on the feet or legs. CLI is associated with high risk for cardiovascular events, including myocardial infarction and in some cases death due to CLI. Auscultation, ankle-brachial index (ABI), magnetic resonance angiography (MR angiography), doppler ultrasound, CT angiography and angiogram are some of the tools to diagnose CLI. Treatment of the disease include medications for pain relief, endovascular treatments such as angioplasty, stents, laser atherectomy, directional atherectomy and surgical treatments such as amputation of the limb.

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Considerable growth is expected in the therapeutics pipeline for CLI in the near future mainly due to rising old-age population, increasing incidence of CLI and its risk factors such as diabetes and obesity. Increasing investment by companies for the research and development of drug candidates for the treatment of CLI is also a major factor driving the growth of pipeline of CLI therapeutics, globally. Lack of an approved treatment for the disease is one of the key factors encouraging companies to invest in the research and development of therapeutics for the treatment of CLI.

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Some of the major players involved in the development of drugs for CLI include Caladrius Biosciences, Inc., Boston Scientific Corporation, Rexgenero Limited, Reven Pharmaceuticals, Inc., Mitsubishi Tanabe Pharma Corporation, Anesiva, Inc., Taiwan Bio Therapeutics Co., Ltd., Beike Biotech India Pvt. Ltd., Pharmicell Co., Ltd., United Therapeutics Corporation, Stempeutics Research Pvt. Ltd.