TNF (tumor necrosis factor) inhibitors are anti-inflammatory drugs. TNF inhibitors help to block the TNF alpha that occurs naturally in the body and causes inflammation. TNF drugs are used to reduce inflammation and stop disease progression by targeting the tumor necrosis factor, which is an inflammation-causing substance. TNF inhibitor drugs are employed to treat inflammatory conditions such as rheumatoid arthritis and juvenile arthritis. Generally, in the healthy person, the TNF levels remain steady. However, in a patient with rheumatoid arthritis, the level of TNF is increasing which leads to more inflammation. TNF inhibitor drugs act as blockers for TNF substances. TNF alpha blockers are highly effective in the treatment of patients with active rheumatoid arthritis. These drugs are used in patients as a conventional second-line treatments.

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Based on drug, the TNF inhibitors market can be segmented into etanercept, infliximab, adalimumab, certolizumab, and golimumab. The adalimumab segment is likely to expand at a significant pace during the forecast period. The drug is effectively used in a broad range of pain management therapies and is widely available over the counter. Based on distribution channel, the TNF inhibitors market can be segmented into hospital pharmacy and retail pharmacy. The hospital pharmacy segment is likely to expand at a significant pace between 2017 and 2025, this is because patients with rheumatoid arthritis, arthritis give more preference to the hospitals for treatment.

Increase in elderly population and rise in the prevalence of rheumatoid arthritis, psoriatic arthritis, and inflammatory bowel disease are some of the factors that drive the TNF inhibitors market. According to the National Health Interview Survey, in 2016, almost 20% of the global population was reported to be suffering from chronic pain, with rheumatoid arthritis being one of the major reasons. Moreover, according to the Center for Disease Control and Prevention, by 2040, approximately 78 million (26%) of the U.S. adults are projected to have arthritis. Owing to this, the consumption of TNF inhibitor dugs is likely to increase rapidly in the near future. However, side-effects associated with the use of TNF inhibitor drugs such as skin irritation, flushing, headache, and abdominal pain are estimated to hinder the market in the next few years.

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In terms of region, the global TNF inhibitors market can be segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America is the leading market share, primarily due to favorable reimbursement policies for pain management prescription drugs in the region. Lenient regulations in Europe are playing a key role in the increased rate of development, approval, and commercialization of innovative molecule combinations in the pain management. This is likely to fuel the market in Europe during the forecast period. The increasing prevalent population and launching of new products are estimated to drive the market in Asia Pacific during the forecast period. Despite sustained growth and development Middle East & Africa had faced several health challenges over the last decade. Factors such as economic resources, adequate health care facilities, and growing burden of communicable diseases are likely to propel the market in the region from 2017 to 2025. Moreover, rheumatology services are limited or non-existent in several parts of sub-Saharan Africa. Hence, making these services available may boost the market in Middle East & Africa during the forecast period.

Major players operating in the global TNF inhibitors market are Pfizer, Boehringer Ingelheim, Novartis, Amgen, Mochida Pharmaceutical, Hanall, BioPharma, GalxoSmithKline, and Janssen Biotech.

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