Chemical Products N-Hydroxysuccinimide Description
White to pale yellow

Chemical Products N-Hydroxysuccinimide Basic Attributes
CAS No：6066-82-6

Molecular Formula ：C4H5NO3

Molecular Mass ：115.09

Exact Mass ：115.026939

PSA ：57.6 A^2

LogP ：-1.4

EINECS ：228-001-3

InChIKeys ：NQTADLQHYWFPDB-UHFFFAOYSA-N

H-bond Acceptor ：3

H-bond Donor ：1

SP3 ：0.50

RBN ：0

Chemical Products N-Hydroxysuccinimide Characteristics
Appearance ：Clear yellow-brown to brown Liquid or Solid

Density ：1.6±0.1 g/cm3

Melting Point ：95-98 °C(lit.)

Bolling Point ：262.4°C at 760 mmHg

Flash Point ：112.5±22.6 °C

Refractive Index ：1.600

Solubility ：H2O: soluble

Storage Condition ：2-8°C

BRN ：113913

Stability ：Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, strong bases. Protect from moisture.

Chemical Products N-Hydroxysuccinimide Safety Information
HS Code ：29251995

UN No. ：NONH for all modes of transport

WGK_Germany ：3

Risk Code ：36/37/38

Safety Instructions ：22-24/25-26-36

Dangerous Mark ：Xi

P Code ：P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, P501

Hazard Statements ：H315

Hazard Note ：Irritant

Chemical Products N-Hydroxysuccinimide Product Usage
Additive used in the carbodiimide method for improved amidations and peptide couplings.

Chemical Products N-Hydroxysuccinimide Production Methods
100g (1.0mol) of succinic anhydride and 70g (1.0mol) of hydroxylamine hydrochloride were heated together to keep the reaction system under negative pressure to remove the generated volatiles, quickly heated to above 125℃, and slowly raised to 160℃ after 1h. The heating was stopped, and when the temperature dropped to 125°C, the liquid reactant was poured into 400 ml of ether and stirred vigorously. After the product solidified, the ether layer was decanted. The cured product was heated to boiling with 400 ml of butanol, filtered hot, and the filtrate was quickly cooled to 0°C. After 1h, it was filtered, and the crystals were washed with butanol and ether in sequence. The resulting crude product was recrystallized with ethyl acetate to obtain 50g of finished product with a yield of 44%.

Chemical Products N-Hydroxysuccinimide Material and Products
Material ：
Succinic acid, 1,3-Diaminopropane, Acetic acid, Succinic Anhydride, Hydroxylamine hydrochloride, BZ-OSU, Diethyl succinate, 1,5-Pentanedioic Acid

Products ：
Imidapril, Enalapril, Aspoxicillin, Arbekacin, PHT-GLY-OSU, GUSPERIMUS

From: https://www.echemi.com/products/pid_Rock8364-n-hydroxysuccinimide.html