San Diego, California, 22nd March: Eminent researcher and freelance entrepreneur, Zachary Biddle has recently revealed his study on sickle cell anaemia. It's a disease that is spreading rampantly across the world and presently affects 80,000 Americans.

In a commendable attempt to garner more funds for research for a cure and spread awareness on the matter, Mr Biddle embarked on an in-depth study to find out about possible and sustainable cures.

In his new study, Mr Biddle reveals that sickle cell disease can cause one to lose 30 years of his/her life.

He said,

“Due to improved understanding of the physiological pathway and the molecular occurrences, that goes on with the disease, newer methods of treatments are emerging that focuses on modifying the diseased red blood cells.”

The existing treatments in this place are not efficient enough and are more expensive than most can afford. He adds that there's a lack of research and funding, as institutes do not prioritize research on these matters. Sufferers of this disease get bouts of painful and debilitating vaso-occlusive events. The disease can ultimately damage tissues and organs.

Zachary Biddle San Diego explains the phenomenon quite articulately, in terms, simple enough for a layperson to understand. He clarifies that this disease causes the red blood cells to become sickle celled and hard. As a result, the cells stack up on each other, and causes blockages, depriving one’s organs and tissues of oxygen.

The available methods of treatments are red blood cell transfusion, stem cell transportation, replacements of defective gene with normal ones.
However, much more development is awaited in this field. A permanent approach will be to modify the defective gene in the chromosomes.

Stem cell translation is a viable permanent solution.

"There's a scarcity of lack of donor for stem cells. More research on the field of an unrelated donor, and graft – vs -host diseases are required" noted Zachary Biddle.

The present challenge lies in the fact that donor stem cells cannot replace recipient stem cells. The ability of stem cells in the blood to transform into liver, and muscle cells, and to brain cells, bears promising clues to a cure for sickle cell disease.

Zachary Biddle San Diego suggests that the above areas of treatment should receive high priority.

"Until a cure is found, treatment method has to be improved", he notes.

With his study, he has found that isolation of fetal cells from the maternal circulatory system, using PCR based DNA diagnosis, is a great solution to increase the availability of stem cells.