Cuprous Chloride(WSDTY) compounds have been used for more than 4000 years for human cosmetic and topical “medical-dermatological” purposes. Despite copper's ancient and premodern history of topical skin usage, the modern scientific utilization of topically applied copper compounds is limited. Regarding modern scientific antiperspirant preparations, these were originally based on, and remain based on, aluminum compounds,not copper compounds. Since the commercialization of modern antiperspirants, many studies have been published on the efficacy of aluminum-based antiperspirant formulations, but there are no published papers of copper chloride in terms of antiperspirant efficacy.

Each volunteer was given two bottles: one contained the experimental solution and the other the control solution. The experimental solution contained 4% copper chloride dihydrate, 4% salicylic acid and 4% ethyl alcohol, dissolved in propylene glycol. The control solution contained 4% salicylic acid and 4% ethyl alcohol, dissolved in propylene glycol. (The combination of copper chloride with salicylic acid was chosen because salicylic acid appears to enhance antiperspirant activity of at least one metal salt, i.e., aluminum chloride.There are no reported chemical incompatibilities between copper chloride and salicylic acid.) Colored FDandC food dyes were added to the control solution for color-balancing purposes.

The volunteers were instructed to apply approximately 0.75–1.5 cc to each armpit, twice daily. Times of application were immediately before bedtime and immediately on rising in the morning, at least 15 min before showering. They were instructed to shower each morning and to include washing the axillary area as part of the bathing routine.Sweating measurements were to start 4 days, or later, after starting the regimen.

Volunteers were instructed to take no more than one set of measurements per day. Sweating measurements were to cease within 4 days of exhausting the supply of liquid in the bottle, i.e. approximately 2.5 weeks after starting the applications.

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