​According to a recent market study published by Transparency Market Research (TMR),the fragment-based drug discovery (FBDD) market has gained momentum due to the efficient and accurate results it offers to the healthcare industry. The market is also experiencing swift growth with the shift in perception from traditional techniques such as high-throughput screening (HTS) to design-intensive approaches that are derived by using structural and computational biology.
Advantages of FBDD Drive Demand from Global Market

The global FBDD market is expected to experience a swell due to the simplicity it offers. Moreover, the time-saving techniques also allow efficient streamlining and quick access to advanced biophysical techniques. Furthermore, as big companies in the global fragment-based drug discovery market join hands with biopharmaceutical companies and CROs, it will not only help the market tighten its grip but will also boost its growth prospects.

The global fragment-based drug discovery market is segmented on the basis of service into fragment screening and fragment optimization. The fragment screening segment is further sub-segmented into biophysical techniques and non-biophysical techniques. The components of the biophysical techniques are nuclear magnetic resonance (NMR) spectroscopy, fluorescence polarization (FP), x-ray crystallography, biolayer interferometry, capillary electrophoresis, differential scanning fluorimetry (DSF) assay (thermal shift), and isothermal titration calorimetry (ITC). On the basis of end-use industry, the global fragment-based drug discovery market is segmented into CROs, academic and research institutions, and biopharmaceutical companies. Regionally, this market is divided into North America, Asia Pacific, Europe, Latin America, and Rest of the World.

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NMR Spectroscopy Emerges as Leading Segment of Global Market

Out of all the services offered by the global fragment-based drug discovery market, nuclear magnetic resonance (NMR) spectroscopy services held the lion’s share, accounting for 19.7% of the total market in 2014. Advantages of NMR services such as ease of operation, reliability, and excellent versatility are some of the factors that will enable its growth to help it retain the position of a leader in the global fragment-based drug discovery market in the next few years. However, the global fragment-based drug discovery market faces restraints such as high cost of procurement and easy availability of cheaper substitutes. These factors are likely to impact the market in a negative way in the coming years.

Biopharmaceutical Companies Bridge Research Gaps with FBDD Techniques

The ability of fragment-based drug discovery methods to identify fragments with low affinity binding is making academic and research institutions, CROs, and pharmaceutical companies demand their services. In 2014, biopharmaceutical companies held a market share of 46.0% in the global fragment-based drug discovery market. The reasons for this are increasing research and development costs, poor product lineup in the pipelines, and low productivity of conventional biopharmaceutical research methods. These negative reasons are forcing the biopharmaceutical companies to bridge the wide gap in the drug discovery processes, which is causing a positive effect on the FBDD market as an alternative drug discovery technique.

The players making a difference in the global fragment-based drug discovery market are Astex Pharmaceuticals, Beactica AB, Alveus Pharmaceuticals Pvt. Ltd., Sygnature Discovery, Crown Bioscience, Inc., Charles River Laboratories International, Inc., Structure Based Design, Inc., Evotec AG, Emerald BioStructures, Inc., Proteros Fragments GmbH, Kinetic Discovery Limited, and Sprint Bioscience.

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