Tissue Engineering is an interdisciplinary field addressed to develop functional three-dimensional tissues combining cells, scaffolds, and bioactive molecules. This field involves scientific areas such as cell biology, chemistry, material science, molecular biology, medicine, and engineering. It can be used to develop functional constructs that can be used to reestablish, maintain or improve the condition of injured body parts or tissues.

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Tissue engineering also assist in regeneration of damaged tissues by combining cells from the body with highly porous scaffold biomaterials. Scaffold biomaterials act as templates for tissue regeneration and guide the growth of new tissue. Tissue regeneration is highly beneficial for clinical management of organ therapeutics such as organ transplantation. The source of cells utilized in tissue engineering can be autologous (from the patient), allogenic (from a human donor but not immunologically identical), or xenogenic (from a different species donor).

Tissue engineering is gaining traction in various areas such as wound care, burn treatment, orthopedics, neurology, urological products, and others. Tissue engineering can play an important role in the management of pediatric patients. Tissue or organs absent at the time of birth, in congenital anomalies such as bladder exstrophy, esophageal atresia, and congenital diaphragmatic hernia pose a serious challenges in surgical repair. Moreover, increasing burn and trauma related injuries are expected to drive the global tissue engineering market growth. According to the American Burn Association 2014 data, nearly 450,000 patients receive hospital and emergency room treatment for burns annually.

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Shortage of donor for various transplantation procedures presents a severe challenge to clinicians worldwide. According to the U.S. government information on organ donation and transplantation, as of 2017 nearly 114,687 people in the U.S. were on waiting lists for transplants of kidneys, hearts, livers, and other organs. Tissue engineering can fulfil the inadequacy of organ transplantation and increasing 3D printing prominence in medical applications for regeneration is anticipated to propel the demand for tissue engineering during the forecast period. Tissue engineering also holds a promising future for the restoration of 3D contour as well as the loss of function for the affected body parts.

Currently available tissue engineering methods face several problems including ineffective cell growth, insufficient, and unstable production of growth factors to stimulate cell communication and proper response and lack of suitable biomaterials and techniques for capturing appropriate physiological architectures. Moreover, inability to control cellular functions and their various properties (biological, mechanical, electrochemical and others) and issues of biomolecular detection and biosensors are other limitations associated with tissue engineering.

Key players operating in the global tissue engineering market include Acelity L.P. Inc., Allergan Plc., Athersys, Inc., B. Braun, BioMimetic Therapeutics, Bio Tissue Technologies, C. R. Bard, International Stem Cell, Integra Lifesciences, Medtronic, Inc., Organogenesis Inc., Osiris Therapeutics, RTI surgical, Inc., Stryker Corporation, Tissue Regenix Group Plc., and Zimmer Biomet.

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