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An excipient is an inactive substance formulated with the active ingredient of a medication for the purpose of bulking-up Route of Administration that contain potent active ingredients. These substances improve bulkiness and dissolution rate of the drug and are crucial in drug delivery within the body. A sugar-based excipient is required if the conventional tablet contains a bitter drug substance or, more importantly, if the tablet is chewable. Sweeteners are added in tablets to impart sweetness to the drugs. Sucrose is the standard against, which all sweeteners, both artificial and natural, are measured.
Apart from being sweeter than sucrose, artificial sweeteners have the advantage of not disturbing blood sugar levels of pre-diabetic or diabetic patients, and they are considered to be non-cariogenic. Sugar-based excipients are widely used as ingredients in pharmaceutical tableting. They are used for taste masking of bitter drugs and as bulking agents. Dextrose, fructose, mannitol, sorbitol, and xylitol are few examples of sugar-based excipients that are mainly used.
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Increasing use of co-processed excipients and rising development of orally disintegrating tablets (ODTs) are major factors that are expected to boost growth of sugar-based excipients market over the forecast period. ODTs are solid dosage forms containing medicinal substances, which disintegrate rapidly, generally in few seconds, when placed on the tongue. Research on delivering biological molecules through the oral route have widened the scope of ODT technology, which further drive growth of the market.
According to the American Pharmaceutical Review 2016, over 35 products have been launched using Zydis ODT technology in over 60 countries worldwide. Furthermore, rising use of sugar alcohols such as mannitol in a wide range of oral dosage and high adaptability in formulation technologies such as ODTs are expected to drive the sugar-based excipients market growth over the forecast period. Sugar alcohol is granular and white like sugar, and is used as a sugar alternative. The sugar alcohols differ in calorie content and sweetness level. Their sweetness level ranges from 50% to 100% that of sugar.
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However, all sugar-based products do not have fast dissolution rate and good compatibility or compressibility. Incompatibility with stringent government regulations for drug manufacturing and excipient usage are expected to hinder sugar-based excipient market growth. For instance, as per the European Medicines Agency, the usage of an excipient should be well reasoned, explaining its role and justification for inclusion of the amount used.
Table of Contents
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Top players in the market
Some of the key players operating in the global sugar-based excipients market include Ashland Inc., Associated British Foods Plc, BASF SE, Colorcon, Inc., Cargill, Inc., DFE Pharma, FMC Corporation, MEGGLE AG, Roquette Group, and The Lubrizol Corporation.
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