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Coronary Artery Disease (CAD) is a medical condition developed due to damaged or diseased blood vessels, which supply blood, nutrients, and oxygen to the heart. Coronary heart disease is characterized by deposition of cholesterol plague in the arteries, which results into inflammation. Increasing deposition of plague eventually narrows the coronary arteries thereby decreasing the blood flow to the heart. Decrease of blood flow to the heart causes shortness of breath and chest pain leading to heart attack after complete blockage. Coronary artery disease is caused by smoking, high blood pressure, high cholesterol, diabetes or insulin resistance, sedentary lifestyle, and hypertension.
Other factors involved in developing coronary artery disease include obesity, physical inactivity, high stress, and unhealthy diet. Coronary artery disease can be prevented by maintaining healthy diet, consumption of low fat and low salt fruits and vegetables, physical activity, and management of stress.
Treatment of coronary artery disease includes cholesterol modifying medications, ACE inhibitors, Aspirin, beta blockers, Calcium channel blockers, and Ranolazine. Surgeries conducted to treat coronary artery disease include Nitroglycerin, Angioplasty, and coronary artery bypass surgery.
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The global market is expected to witness significant growth due to robust pipeline of drugs over the forecast period (2018-2026). For instance, hydroxychloroquine sulfate tablets sponsored by first affiliated hospital of Xi’an Jiaotong university, China is in the fourth phase of clinical trials, this drug suppresses symptoms of coronary artery disease. Atorvastatin sponsored by university health network, Toronto has completed phase two clinical trials in 2014, this drug reduces the risk of heart attack and myocardial infraction. PADMA 28 sponsored by University hospital Inselsiptal, Berne has completed phase 2 clinical trials in 2013, this drug has beneficial effect on arterial system, the autonomic nervous system and blood inflammatory markers in patients with coronary artery disease.
Furthermore, approval of new drugs for coronary artery disease is another factor driving growth of the coronary artery disease therapeutics market. For instance, in 2016, the U.S. FDA approved Yosprala (Aspirin and Omeprazole) by Aralez Pharmaceuticals, a Canada-based company, this drug is used to prevent cardiovascular diseases. In 2015, FDA approved Repatha by Amgen Inc. This drug is used to treat high cholesterol. In 2015, FDA approved Prestalia by Symplmed Pharmaceuticals LLC, this drug is used to treat hypertension for people suffering with heart disorders. Later in 2017, Prestalia was acquired by Marina Biotech Inc.
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Top players in the market
According to a survey conducted by Centers for disease control and prevention (CDC), in 2015, coronary heart disease kills more than 370,000 people annually in the U.S. out of which more than 92% had chest pain as a major symptom. For instance, in 2017, Lupin, India-based Company received FDA approval to launch generic version of Nadolol Tablets, indicated for the treatment of hypertension and angina pectoris.
Key players operating in coronary artery disease therapeutics market include Astra Zeneca, Gilead, Novartis, Pfizer, Bayer, Merck & Co, Glaxo Smith Kline, and Mylan N.V.
Research methodology adopted by Coherent Market Insights
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• Primary Research (Trade Surveys and Experts Interviews)
• Desk Research
• Proprietor Data Analytics Model
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