Oligonucleotide synthesis is the chemical synthesis of comparatively short fragments of nucleic acids with clear chemical structure (sequence). This technique is very useful in modern laboratory practice due to its rapid and low-cost access to custom-made oligonucleotides of the desired sequence. Synthetic oligonucleotides stand for short stretches of single stranded DNA fragments which are not isolated from natural sources but bring together from mononucleotide units by chemical synthesis according to a clear sequence. Oligonucleotides used in various applications in molecular biology and medicine such as antisense oligonucleotides, small interfering RNA, primers for DNA sequencing and amplification, examines for detecting complementary DNA or RNA via molecular hybridization, tools for the targeted introduction of alterations and restriction sites, and for the synthesis of artificial genes.

Drivers and Restraints:

The oligonucleotide synthesis market is growing in continuously, because of growing government investments and R&D spending in pharmaceutical and biotechnology companies and the use of synthesized oligonucleotides in molecular diagnostics and clinical uses. For instance, according to ABPI organization, the global pharmaceutical industry invested above US$1.36 trillion in R&D in the period from 2007 to 2016 and estimates to rise $181 billion by 2022. In addition, the falling cost of sequencing has given rise in demand for custom-made nucleotides for desired sequence through research, genetic testing, drug development, and forensic applications. This, led to propel the demand for oligonucleotide synthesis across various healthcare industries. Moreover, synthetic oligonucleotides deliver several benefits offered by molecular diagnostics. Growing clinical applications, such as the nucleic acid application methods are the reference methods and are very valuable for carrying out molecular diagnosis in several diseases such as detection of infectious diseases, such as hepatitis. Furthermore, oligonucleotide synthesis is an essential part of several ongoing genetic research studies. Therefore the growing investments in genetic research are expected to propel demand for custom synthesis of different classes of oligos including decoys, aptamers, immunostimulatory, antisense, siRNA, and miRNA. Such factor provide an opportunity to the target market. However high cost of research and development is restring factor for target market growth.

Segmentation:

The global oligonucleotide synthesis market is segmented based product type, type, by application and region.

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On the basis of Product Type, the global oligonucleotide synthesis market is segmented into Synthesized Oligonucleotide Product, Reagents and equipment. The synthesized oligonucleotide product is expected to dominate the segment, because of growing demand for oligonucleotide-based drugs and the arrival of new customers in the oligo drug development arena. On the basis of type, the target market is classified into custom oligos and predesigned oligos. Based on application, the global market is segmented into research, diagnostics, and therapeutics. Research application segment is expected to dominate the segment due to increasing investment in research and development, and the important of oligonucleotide synthesis in several ongoing genetic research studies such factor boost the demand for target market.

Based on region the global oligonucleotide synthesis market is segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. North America is expected to dominate the market, due to the growing R&D activities and the rising number of oligonucleotide-based drugs/therapies being approved by the FDA. Additionally, the presence of better health care infrastructure and increasing usage of oligonucleotides by medicinal companies of the region provide strong growth to the market. Asia Pacific is likely to high CAGR in forecast period due to the rapid acceptance of sequencing, array technology, and PCR products because of fast progress in genomics studies and the healthcare sector. Japan and China are measured as the most attractive markets with respect to development and growth opportunities present in these countries.

Key Players:

The key players operating the global Oligonucleotide synthesis market involves Agilent Technologies, Inc., ATDBio Ltd., Bio-Synthesis, Inc., BioAutomation Corporation, LGC Biosearch Technologies, Biogen International, Sarepta Therapeutics, Eurofins Genomics, Eurogentec, GeneDesign, Inc., GE Healthcare, and GenScript, Inc. The key players in the market are focusing on increasing production with development of product. For instance, on June 18th 2019, Agilent Technologies announced the opening of a production facility in Colorado which is double of is current production capacity, and aim to develop and manufacture oligos.

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