One of the most common food supplement groups is also called fat burners.' The reasons why these supplements became common are generally the proposed health changes, efficiency improvements, weight loss, and a combination of these factors. The definition of "fat burners" is used to describe supplements claiming to significantly increase the metabolism of fat or energy intake, inhibit fat absorption, increase weight loss, increase fat oxidation during practice, or in some way induce long-term adaptations that foster fat metabolism. Such supplements also contain many ingredients, each with its own proposed action mechanism. A variety of these compounds are also believed to be combined to have additive effects.
Some supplements have been proposed to increase fat metabolism which discussed below
Caffeine: Caffeine (1,3,7‐trimethylxanthine) is an alkaloid derivative found naturally in, and added to, a variety of foods and beverages. Most of the caffeinated beverages consumed worldwide are extracted from coffee beans or tea leaves or eaten as chocolate derived from the cacao bean. There are a variety of other metabolites in coffee and tea including other alkaloids (theobromine, paraxanthine, theophylline) and polyphenols (tannins and flavonoids). Consumption of caffeine-containing tablets and supplemented foods should not be directly equated to the consumption of tea and coffee, especially from a health perspective. Caffeine is absorbed from foods and beverages with a time to peak plasma concentration of 30–90 min and half‐life of approximately 4–6 h. Caffeine is extensively metabolized by the cytochrome P‐450 oxidase system with ∼1–3% being excreted in the urine as free caffeine.
L‐carnitine: Over the past twenty years, much attention has been paid to L‐carnitine (carnitine), a substance present in meat at relatively high levels (the Latin word caro‐carnis means meat or muscle). The fat metabolism, fat mass reduction, and mass muscle development claim carnitine. Carnitine, therefore, is also used for weight loss, fat reduction, and "sharpness" enhancement. Athletes use carnitine to improve fat oxidation and repair glycogen in their muscles. L‐carnitine is extracted in the diet from red meat and milk products and the body's endogenous manufacture. Even when dietary carnitine is not adequate to keep a functional body (for this reason carnitine is not treated as a vitamin but as a substance like a vitamin) to healthy human beings, it still allows enough methionine and lysine. Carnitine is synthesized to contain only 1.6 percent of a total body carnitine store in the liver and kidneys. Approximately 98% of the human carnitine is present in skeletal and cardiac muscles. Skeleton muscle and heart rely on the circulation of carnitine containing approximately 0,5% carnitine in the entire body.

Forskolin: Forskolin is an Indian Coleus plant manufactured diterpenes of the labdane family (Coleus forskohlii). In the study and research of cell physiology, forskolin is also used to increase cAMP. Forskolin's effects on cAMP were detailed since the 1980s and can be found in both isolated cell preparations and intact teaching. This mechanism can lead to activation of hormonal lipase in humans following forskolin intake and may allow greater lipolysis, which can lead to further fat oxidation.

Fucoxanthin: Fucoxanthin is an edible brown seaweed carotenoid (Undaria pinnatifida). Long-term supplementation of fucoxanthin has been shown to contribute to weight loss in clinical trials.

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Bodybuilders usually adhere to scientific muscle growth guidelines, especially during off-season training. Their pre-contest preparation indeed requires unnecessary cardiovascular training that also drives muscle mass loss, and eventually decreases physical activity.