-Physician’s Seal, LLC®, innovators of REMfresh® (CRA-melatonin™), a clinically studied, drug-free, nonprescription sleep brand, revealed positive results of a nationwide survey conducted among 863 U.S. primary care physicians with certification in sleep disorders. These primary sleep specialists broadened their endorsement for REMfresh as both the #1 recommended modified-release melatonin brand for the second consecutive year and the #1 recommended melatonin brand overall for the first year for sleep management. “Growing, widespread adoption of REMfresh among primary care physicians with certification in sleep disorders reflects an increased willingness to recommend this brand based on their real-world experience in receiving positive feedback from their patients who suffer from sleep disturbances,” said David C. Brodner, M.D., a leading sleep specialist who is Double Board-Certified in Otolaryngology – Head of Neck Surgery as well as Sleep Medicine, Founder and Principle Physician at the Center for Sinus, Allergy, and Sleep Wellness, in Palm Beach County, Florida and Senior Medical Advisor for Physician’s Seal, LLC. Over 5,000 healthcare practitioners are estimated to have used REMfresh for their patients. About IQVIA ProVoice Survey ProVoice has the largest sample size of any professional healthcare survey in the U.S., with nearly 60,000 respondents across physicians, nurse practitioners, physician assistants, optometrists, dentist and hygienists, measuring recommendations across more than 120 over-the-counter categories. Manufacturers use ProVoice for claim substantiation, promotion measurement and HCP targeting. IQVIA fielded a U.S. survey among 863 primary care physicians with certification in sleep disorders between January 22, 2019, through February 24, 2019, for Physician’s Seal. The ProVoice survey methodology validated the claim at a 95 percent confidence level that for the second year, “REMfresh® is the #1 recommended modified-release melatonin brand among primary care physicians with certification in sleep disorders, and for the first year as the #1 recommended melatonin brand among this same cohort. IQVIA is a leading global provider of advanced analytics, technology solutions and contract research services to the life sciences industry formed through the merger of IMS Health and Quintiles. About Nonprescription REMfresh® REMfresh® (CRA-melatonin;) is the first and only, continuous release and absorption formulation of 0.5mg (Lite), 2 mg and 5mg (Extra Strength) UltraMel® melatonin. UltraMel melatonin is a high-quality, 99 percent ultra-pure melatonin sourced from Western Europe exclusively for Physician’s Seal. REMfresh caplets continuously release bioavailable, 99 percent ultra-pure melatonin over 7 hours, which may help a person fall asleep faster, stay asleep longer and experience quality sleep, such as deep sleep and REM sleep. REM Absorption Kinetics Trial (REMAKT), a U.S.-based randomized, crossover pharmacokinetic (PK) evaluation study in healthy, non-smoking adults compared REMfresh (CRA-melatonin) with a market-leading, immediate-release melatonin (IR-melatonin). The study results, which were peer-reviewed and presented at SLEEP 2017 and 2018, showed that melatonin levels with REMfresh exceeded the targeted sleep maintenance threshold for a median of 6.7 hours, compared with 3.7 hours with the leading IR-melatonin. Conversely, the levels of the market-leading IR-melatonin formulation dramatically increased 23 times greater than the targeted levels of exogenous melatonin for sleep maintenance and had a rapid decline in serum levels that did not allow melatonin levels to be maintained beyond 4 hours.