Description

Type 2 Diabetes Mellitus (T2DM) is a metabolic disease characterized by chronic hyperglycemia (high blood glucose levels). Global prevalence has risen rapidly in the past several decades, particularly in line with obesity. This has been attributed to a range of factors, including economic development, increasing urbanization, aging populations, and changes in lifestyle patterns such as reduced levels of physical activity and consumption of higher-calorie diets.

This has led to strong commercial interest in the development of T2DM therapeutics. The current market is large and diverse, comprising several drug classes, including generic and branded drugs. Owing to the range of therapeutic options available, the treatment algorithm is complex. However, current treatment regimens are often associated with limited long-term efficacy, complex and inconvenient dosing regimens, and undesirable side effects such as weight gain and hypoglycemia (low blood glucose levels).

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Scope

Metformin monotherapy will remain the first-line pharmacotherapy for T2DM.
The emergence of several new drug classes over the past decade, namely the Glucagon-Like Peptide-1 (GLP-1) receptor agonists, Dipeptidyl Peptidase 4 (DPP-4) inhibitors, and Sodium–Glucose Cotransporter 2 (SGLT-2) inhibitors, has led to considerable market growth.
Which products lead these drug classes and what threats do they face from the pipeline?
How will the continued uptake of newer drug classes impact established drug classes such as the sulfonylureas and thiazolidinediones?
Leading insulin therapy Lantus (insulin glargine) recently lost patent protection in most major markets.
Will recently approved insulin therapies such as Tresiba (insulin degludec) and Toujeo (insulin glargine) be able to capture a significant portion of Lantus’ market share?
The pipeline is large and highly innovative, comprising a range of molecule types and molecular targets.
How do different molecule types and molecular targets compare in terms of average failure rate, clinical trial duration, and clinical trial size?
Which late-stage pipeline molecules show the most promise and how will they impact the treatment algorithm over the forecast period?
Which late-stage pipeline molecules are expected to generate the highest revenues?
Over the 2014–2021 forecast period, the global T2DM market is expected to increase in value at a CAGR of 7.5% from $23.5 billion to $39.0 billion.
How do prevalence, diagnosis, and treatment patterns vary in the eight major markets?
Which factors will drive market growth most significantly?
Strategic consolidation activity in T2DM is considerable, with US-based companies being key players.
Do T2DM products tend to attract high levels of investment?

Reasons to buy

Understand the clinical context of the T2DM indication and the global burden of the disease by considering epidemiology, symptoms, etiology, pathophysiology, co-morbidities and complications, disease classification, disease prognosis, and treatment options
Appreciate the current T2DM marketed products landscape, including the dominant therapeutic strategies, products, and companies, and recognize gaps within the market and areas of unmet need
Identify key pipeline trends in molecule type and molecular target
Recognize the late-stage pipeline molecules that have demonstrated strong therapeutic potential in T2DM by examining clinical trial data and multi-scenario product forecast projections
Consider market opportunities and potential risks by examining trends in T2DM clinical trial size, duration, and failure rate by phase of development, molecule type, and molecular target
Discern variances in treatment usage patterns, annual therapy costs, and market growth projections for the US, Canada, the UK, France, Germany, Italy, Spain, and Japan
Discover how strategic consolidations have shaped the current T2DM pipeline and marketed products landscapes


1 Table of Contents

1 Table of Contents 4
1.1 List of Tables 7
1.2 List of Figures 7

2 Introduction 9

2.1 Disease Overview 9
2.2 Epidemiology 9
2.3 Symptoms 10
2.4 Etiology 10
2.5 Pathophysiology 11
2.6 Co-morbidities and Complications 13
2.7 Classification 15
2.8 Prognosis 15
2.9 Diagnosis 16
2.10 Assessing Treatment Effectiveness 17
2.11 Treatment Algorithm 17
2.12 Non-insulin T2DM Therapies 19
2.12.1 Biguanides 19
2.12.2 Sulfonylureas and Meglitinides 19
2.12.3 Thiazolidinediones 20
2.12.4 Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists and Dipeptidyl Peptidase 4 (DPP-4) Inhibitors 20
2.12.5 Sodium–Glucose Linked Transporter-2 (SGLT-2) Inhibitors 21
2.12.6 Other Non-insulin Therapies 21
2.13 Insulin T2DM Therapies 22
2.14 Treatment Segments 24
2.14.1 Non-insulin therapies 24
2.14.2 Insulin Therapies 39

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