The primary use of the blood substitute is to provide a temporary support to the circulation system whenever the conditions demand. These conditions may be blood transfusions or surgeries in which blood substitutes are mostly focused on the basic role of transporting the oxygen for a short duration. There various blood substitutes available such as Perflurocarbons (PFC) emulsions and Hemoglobin-based oxygen carriers. The Perflurocarbons are derived from a group of hydrocarbons in which the hydrogen atoms are replaced by fluorine atoms and has been beneficial in creation of artificial blood during surgeries.

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The most common PFCs are the Perfluorodecalin and Perflubron. The major advantage of PFCs is they permit easy transportation of the oxygen to the body. However, the common side effects cited by use of these PFCs are decrease in the blood platelet counts and causes flu-like symptoms in the patients. While, the hemoglobin based oxygen carriers have been successfully being used to mimic the role of oxygen carrier role of hemoglobin in the body. Since, this substitute has been available in much larger quantities, can be stored for a longer duration and can be sterilized makes it a more preferred choice by the physicians. The chief problems associated with synthetic blood substitutes are anaphylactic shock especially in patients who are frequent users of these substitutes. Despite, significant research there has still a huge gap in meeting these safety requirements. Companies are now focusing towards introduction of innovative biotechnological techniques to introduce an effective blood substitute. The company OPK Biotech, managed to successfully develop hemoglobin-oxygen based carrier through chemical stabilization of bovine hemoglobin. This flagship product named “Hemopure” has been approved and sold in South Africa since past several years. Moreover, the U.S. Armed Services has also been conducting research since Vietnam War which has helped them to introduce substitutes such as dried powder that can be stored, packed and transported and then reconstituted as

A new report from Transparency Market Research, titled ‘Synthetic Blood Substitutes Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019,’ states that the growth of the global synthetic blood substitutes market is propelled by the increasing cases of trauma including road accidents, burns, and military wars. The rise in the aging population has resulted in the growing need for surgical interventions such as cardiac surgeries, blood cancer treatment, and others. All these factors are expected to propel the global synthetic blood substitutes market in the next few years.

The key use of blood substitutes is to deliver a temporary support to the blood circulation system whenever required. Blood substitutes are used in situations such as surgeries or blood transfusions wherein the former are used for transporting oxygen for a specific duration. Among the blood substitutes available on the global market are hemoglobin-based oxygen carriers and perfluorocarbons (PFC) emulsions. The perfluorocarbons are primarily derived from a specific group of hydrocarbons wherein fluorine atoms replace the hydrogen atoms. This has been very beneficial in the creation of artificial blood at the time of surgeries.

Perflubron and perfluorodecalin are two of the most common PFCs. The most important advantage of PFCs is that they allow the easy transportation of oxygen throughout the body. However, one of the common side effects of PFCs is the decrease in the platelet counts. However, an excess of PFCs may also cause flu-like symptoms in the body. Hemoglobin-based oxygen carriers are successfully used to imitate the duty of oxygen carriers to carry hemoglobin in the body. People who frequently use synthetic blood substitutes may have to deal with anaphylactic shock. Irrespective of research and development activities, there is still a big gap in meeting the basic safety requirements for using synthetic blood substitutes. These factors are expected to hamper the growth of the global synthetic blood substitutes market in the years to come.

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However, the leading companies in the global synthetic blood substitutes market are constantly focusing on the introduction of new biotechnological techniques to develop and introduce effective synthetic blood substitutes. For instance, OPK Biotech, a leading company in the global synthetic blood substitutes market, managed to develop a hemoglobin-oxygen-based blood carrier through the chemical stabilization of bovine hemoglobin. This innovative product, Hemopure, is being sold in South Africa. The introduction of many such products is expected to contribute towards the growth of the global synthetic blood substitutes market in the years to come.
By geography, the global synthetic blood substitutes market is divided into Europe, Asia Pacific, North America, and Rest of the World. Biopure (Hemopure), Sangart, Northfield (Polyheme), and Dendritech are some of the leading players in the global synthetic blood substitutes market.

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