The severe and pulsating headache caused during a migraine attack is due to disturbances in the neural and vascular systems in the brain. Scientists still don’t know the exact physiological mechanisms behind this condition but they are aware that certain factors like stress, changes in hormones, specific dietary patterns, and deprivation of sleep can instigate an attack.
In these cases, over-the-counter painkillers may not be effective for the majority of people, hence, they will require specific migraine medication.
Types of Migraine Medications
The anti-migraine drugs can be divided into mainly two broad types.
Acute treatments
To use abortive types of migraine medications the following should be used in an attempt to reverse the course of pain experienced from migraines. These include:
1. Triptans.
How They Work: Triptans are a medication that bridges the gap between two nerve receptors causing them to lessen inflammation levels in the blood vessels leading to a reduction in brain migraines.
Examples: sumatriptan imitrex, rizatriptan maxalt, and zapmitriptan zoming.
Best For: migraines of moderate to severe severity, particularly those accompanied by both mild or severe nausea or light intensity.
2. Apresin and Arthotec.
How They Work: NSAIDs are mentioned within these kinds of medications because some fall under the umbrella of inflammatory pain relievers which target widespread general pain.
Examples: Ibuprofen Advil, Naproxen Aleve, as well as prescription-level aspirin.
Limitations: However, there are certain stipulations; severe migraines may become resistant, which is a risk for medications that can potentially lead to overuse or excessive use which causes a rebound headache.
3. CGRP
How They Work: Antagonists CGRP actively target a specific protein that ultimately causes the formation of pain associated with migraines.
Examples: Rimegepnd Nurtec ODT, ubrogepant ubrelvy.
Benefits: Beneficial for people who have not had much luck with triptan medications.
4. Medications of a higher order.
How They Work: Provide aid in disabling nausea and vomiting that is not limited to but torsioned in the domain of migraine headache episodes.
Examples: Metoclopramide Reglan, Prochlorperazine Compazine.
Oftentimes they are combined with: Triptans or analgesics.
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