The skill of surgery has progressed over the years. Suture like threads produced from a wide-range of substances were used prior as a mechanical closure for the wounds. Surgical adhesives and hemostats consist of five new families, which consist of fibrin glue, cyanoacrylate, polyethylene glycol polymer, albumin cross linked with glutaraldehyde and bovine collagen and thrombin. Now in the last 30 years, fibrin glue has beenused in various indications throughout all surgical fields.

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Fibrin glue is a derivative of human blood products andanimaland it is mostly withdrawn from collective plasma and comprises of different quantities of purified and virally inactivated human proteins. Biological fibrin glue typically contains two basic components such as human thrombin and human fibrinogen, together with a fibrinolysis inhibitor to prevent fibrin degradation during the storage. The various features of fibrin glue are high surface adherence strength, high internal bond strength and capability to improve tissue regeneration and clot formation. Fibrin glue is primarily used inhemostasis, but it isalso used to heal the wounds and as biological sealants,it in different situations such as air, gastrointestinal, bile and lymphatic leaks on a larger scale. Fibrin glue reducesthe threat of infection, offersquick hemostasis on the treated part, and improves cosmesis. Fibrin glue permits the surgeon to execute the operation using minor incision and with reduced tissue trauma. It also encourages natural tissue healing. On the other hand, one of the drawback of fibrin glue is the risk of passing on of infectious organisms from human bodies to the glue. Additionally, their role in tissue engineering is recently under investigation. Recently fibrin glue has received approval from U.S. FDA and European Union for their use in spleen trauma, cardiovascular surgery and for the closure of colostomies. Tisseel, biocol, and beriplast are some of the commercially prepared fibrin sealants.

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The global fibrin glue market is segmented based on application and geography. The applications of fibrin glue arein cardiac surgery, pulmonary surgery, burn bleeding, vascular surgeries, orthopedic surgeries, lacerations of liver and spleen, neurosurgery, plastic surgery,general surgery and wound management. The burn bleeding and cardiac surgeriessegment dominates the fibrin glue market in applications category.

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