Cell lines are one the major tools used in research for studying the normal physiology and biochemistry of cells, the effects of drugs and toxic compounds on the cells, drug screening and development and large-scale manufacturing of biological compounds. Cell culture is the process by which cells are grown under controlled conditions derived from microbial or animal cells. Cell lines are a subculture of primary culture also known as sub-clone. Cell lines derived from primary cultures have a limited lifespan, after subsequent cultures, cells with the highest growth capacity dominate which are selected for further cell development. An immortalized cell line can proliferate indefinitely either through random mutation or deliberate modification which are useful especially for the production of therapeutics.
The cell line development service market is expected to grow at a double digit CAGR from 2022 to 2030 to reach $2,093.2 million by 2030. Increasing trend of biologics outsourcing and increasing approval and demand for biologics and biosimilars are driving the market. While, growing incidence rate of oncology, autoimmune disorders, infectious diseases & genetic disorders, growth in research activities related to the diseases and also recombinant cell lines for the production recombinant biopharmaceutical proteins and technological advancements in cell line engineering (gene editing tools) & cell line development technologies, screening technologies and process development are giving immense growth opportunities for the market. However, tedious procedure involved in the development of stable cell lines and high risk of contamination are restraining the market. Furthermore, stringent and complex regulations and the high cost and technical requirement to adhere to accreditations such as GMP are posing threat to the industry.
Cell line development service global market is classified based on the expression system, cell line type, application and geography. Based on expression system, cell line development service global market is segmented into microbial, mammalian and others. Among these, mammalian expression system is accounted for the highest revenue of in 2022 and is expected to grow at a double digit CAGR from 2022 to 2030. Based on the cell line type, global cell line development service market is segmented into CHO, Mouse Myeloma (NS0; Sp2/0), Human Embryonic Kidney (HEK), Baby Hamster Kidney (BHK), Hybridoma, Human Embryonic Retina (PER.C6) and others. Among these, CHO cell line accounted for the highest revenue in 2022 and is expected to grow at an early teen CAGR from 2022 to 2030. Based on application, cell line development service global market is segmented into research, bioproduction and diagnostics. Among these, bioproduction segment accounted for the highest revenue in 2022 and is expected to grow at a double digit CAGR from 2022 to 2030. Based on the geography, cell line development service global market is segmented into North America, Europe, Asia-Pacific and Rest of the world. North America commanded the highest revenue of the global cell line development services market in 2022. The market is expected to grow at a high single digit CAGR from 2022 to 2030. Asia-Pacific region is expected to grow at a strong CAGR of 12.2% during the forecasted period.