Numerous studies have confirmed that novel coronavirus infection in humans produced long-lasting side effects even after the symptoms of the initial disease disappeared completely, which we call long-term COVID-19 symptoms.
During rehabilitation after being infected with COVID-19, many patients said they experienced "brain fog".
According to the current medical research results and the generally agreed consensus, there may be the following four ways for the novel coronavirus to directly invade the brain:
(1) The coronavirus invades the brain directly through olfactory organ tissues and the olfactory nervous system.
(2) The coronavirus crosses the blood vessels, breaks through the blood-brain barrier, and directly invades the brain.
(3) The coronavirus passes through blood vessels and leaks to the brain at certain weak spots in ventricular organs, where these endothelial cells are not tightly connected and also lack an astrocyte interception barrier.
(4) The coronavirus infects peripheral nerve cells in human organ tissues, and is transported retrogradely to the brain end through the Dynein protein, and then leaks to the brain by latency into extracellular vesicles (EV). This possibility has not yet been fully substantiated.
Thess are the process of the coronavirus invading the brain through the blood-brain barrier or the parenchyma of ventricular organs:
(1) The blood-brain barrier is usually composed of two modes: one is composed of an intercepting network combined of dense astrocytes, and the other is composed of a dense monolayer choroid plexus (CP) epithelial cells to form the blood-brain barrier BCSFB..
(2) The coronavirus is transported to the central nervous system through capillary blood, then infects endothelial cells of microvessels and crosses them, and then breaks through the intercepted network composed of dense astrocytes to enter the brain ventricular lumen.
(3) The coronavirus is transported to the central nervous system via capillary blood and then infects the endothelial cells of the microvessels and crosses them, then infects the monolayer choroid plexus (CP) epithelial cells and crosses them to enter the brain ventricular lumen.
(4) In addition to the blood-brain barrier, novel coronavirus enters the brain ventricular lumen from these loopholes in certain weak spots of ventricular organs, where these endothelial cells are not tightly connected and there is also a lack of astrocyte interception barrier.
(5) Once the coronavirus enters the brain, it begins to invade tissues and organs and central neuronal cells in the ventricular cavity, and start to replicat, proliferation, propagation.
(6) Viral infection activates the immune system in the brain and turns on PAMPs (pathogen-associated molecular patterns) and DAMPs (damage-associated molecular patterns), which in turn produce PRRs (cytosolic pattern recognition receptors).
(7) PRRs (cytosolic pattern recognition receptors) include: Cytokines (cytokines), Chemokines (chemokines), ROS (reactive oxygen species), AMP (antimicrobial protein peptides, which are inflammatory mediators and barrier fragments in infected phagocytes).
(8) At this point, the inflammation of the brain begins to spread.
Long Covid Care center said that from the above pathological deduction steps, novel coronavirus infection triggered an inflammatory response in the brain, which in turn produced a series of neurodegenerative lesions, causing long-term COVID-19 symptoms and being the cause of brain fog symptoms. When we develop long COVID symptoms of brain fog, we must treat it seriously, for brain fog will further develop into early Alzheimer's disease or Parkinson's disease. Therefore, medical attention should be sought as soon as possible when symptoms of brain fog occur.
Patients With Brain Fog After Infection With Covid-19 Are Welcome To Contact With Our Long Covid Care Center.
contact our Long COVID Care Center for assistance.

Phone/Whatsapp: +852 5765 5768
Email: [email protected]