When alcohol enters your bloodstream, it tells your pituitary gland not to produce vasopressin, which is the hormone that typically keeps your body lubed up with moisture. Without vasopressin, liquids get syphoned straight to your bladder, which is why you really open the floodgates after the first time you pee during a boozy evening. When you're drinking, you lose about four times more liquid than you gain, which also causes the dehydration that leads to that wonderful cotton mouth and headache that come with a hangover. Ever wonder why exactly dehydration causes a headache? It's because your organs are so desperate they steal water from your brain, which causes your brain to shrink. A shrunken brain pulls on the membranes that connect the brain to the skull, and that, naturally, hurts like a mother.

A hangover is the experience of various unpleasant physiological and psychological effects following the consumption of ethanol, as found in wine, beer and distilled spirits. Hangovers can last for several hours or for more than 24 hours. Typical symptoms of a hangover may include a headache, drowsiness, concentration problems, dry mouth, dizziness, fatigue, gastrointestinal distress (e.g., vomiting), an absence of hunger, depression, sweating, nausea, hyper-excitability and anxiety.
While the causes of a hangover are still poorly understood, several factors are known to be involved including acetaldehyde accumulation, changes in the immune system and glucose metabolism, dehydration, metabolic acidosis, disturbed prostaglandin synthesis, increased cardiac output, vasodilatation, sleep deprivation and malnutrition. Beverage-specific effects of additives or by-products such as congeners in alcoholic beverages also play an important role. The symptoms occur typically after the intoxicating effect of the alcohol begins to wear off, generally the morning after a night of heavy drinking

Though many possible remedies and folk cures have been suggested, there is no compelling evidence to suggest that any are effective for preventing or treating alcohol hangover. Avoiding alcohol or drinking in moderation are the most effective ways to avoid a hangover. The socioeconomic consequences and health risks of alcohol hangover include workplace absenteeism, impaired job performance, reduced productivity and poor academic achievement. A hangover may also compromise potentially dangerous daily activities such as driving a car or operating heavy machinery
Hangover symptoms
Hangover symptoms typically begin when your blood alcohol content drops significantly and is at or near zero. They're usually in full effect the morning after a night of heavy drinking. Depending on what and how much you drank, you may notice:
• Fatigue and weakness
• Excessive thirst and dry mouth
• Headaches and muscle aches
• Nausea, vomiting or stomach pain
• Poor or decreased sleep
• Increased sensitivity to light and sound
• Dizziness or a sense of the room spinning
• Shakiness
• Decreased ability to concentrate
• Mood disturbances, such as depression, anxiety and irritability
• Rapid heartbeat

Causes

The processes which lead to hangovers are still poorly understood. Several pathophysiological changes may give rise to the alcohol hangover including increased levels of acetaldehyde, hormonal alterations of the cytokine pathways and a decrease of the availability of glucose. Additionally, associated phenomena are dehydration, metabolic acidosis, disturbed prostaglandin synthesis, increased cardiac output, vasodilation, sleep deprivation and insufficient eating. Some complex organic molecules found in alcoholic beverages known as congeners may play an important role in producing hangover effects because some, such as methanol, is metabolized to the notably toxic substances formaldehyde and formic acid.
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