Keto BodyTone: Via Wikimedia CommonsUnder conditions of abundant glucose the brain is primarily converting glucose to pyruvate . Pyruvate is then shuttled into the mitochondria and converted into acetyl CoA with the help of a very important enzyme called pyruvate dehydrogenase . I’m going to come back to this enzyme, in part II of this series, because this is where the story gets very interesting. Acetyl CoA is then combined with oxaloacetate and so begins the Krebs Cycle, which generates all the reducing agents to feed the ETC and generate massive amounts of ATP.

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