Protein A is a bacterial protein, which has capacity to bind mammalian antibodies of class immunoglobulin G with great affinity. Protein G binds to all subclasses of human immunoglobulin G (IgG) makes it useful for purifying polyclonal or monoclonal IgG antibodies whose subclasses have not been determined. Monoclonal antibodies are defined as ‘an antibody produced by a single clone of cells'. It can be used to carry drugs, toxins, or radioactive substances traditional to cancer cells. Monoclonal antibodies have been showing promising results in the management of chronic diseases such as cancers and rheumatoid arthritis. These are essential and are broadly used as purification and separation materials due to high resolution, across the biopharmaceutical industry. Natural protein A can be produced from Staphylococcus aureus, though protein A is now commonly produced recombinant in Escherichia coli. Chromatography with these has several advantages as a separation method, over conventional techniques such as solvent extraction, crystallization, and distillation.
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Geographically, North America accounted for the leading share in the global protein A resin market, due to the large number of clinical trials for the monoclonal antibody based therapeutics and increasing traction for biosimilars with the recent U.S. Food and Drugs Administration (FDA) in the region. The U.S. contributed largest revenue to the North American as well as global protein A resin industry. The country is expected to remain the largest market for protein A resin globally during the forecast period. This market is expected to witness the highest growth in Asia-Pacific during the forecast period, owing to the increasing compliance for biosimilars and shifting global attentiveness for expanding biopharmaceutical manufacturing capacities in the emerging economies of the region.
Protein A Resin Market
On the basis of Product, the protein A resin market is classified into:
◦ Natural Protein A Resin
◦ Recombinant Protein A Resin
On the basis of Application, the protein A resin market is classified into:
◦ Antibody Purification
On the basis of Matrix Type, the protein A resins is classified into:
◦ Glass or Silica
◦ Agarose and
◦ Organic Polymer
On the basis of end users, the protein A resins is classified into:
◦ Biopharmaceutical Manufacturers
◦ Clinical Research Laboratories and
◦ Academic Institutions
Key Players: Thermo Fisher Scientific Inc., General Electric Company, Merck KGaA, Repligen Corporation, Tosoh Corporation, Expedeon Ltd., Novasep, and GenScript, among others.
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