During any transplant of stem cell and bone marrow some complications arises that may be mild or severe, those are the graft versus host disease (Gvhd) they occur especially in immune-compromised patients. During cancer treatment, the radioactive agents or the chemicals affects the healthy cells along with the cancer cells. Reconstruction of body cells affected during cancer treatment can be fixed using stem cell and bone marrow transplant. Following a high dose of chemotherapy, the bone marrow is received by patient the donor through infusion, which helps with resumption of blood cells production. Graft versus host disease occurs when particular type of white blood cells are not compatible with the existing cell type and thus, leads to an attack by the transplanted cells on the recipient body. It is a difficult procedure to diagnose the agents and the compatibility during the transplant. Symptoms of Gvhd are usually not too severe, though in some cases it can be fatal. During autologous transplant, the patient is free from such complications. Also, prior to the transplant, cells of the donor and recipient are closely screened and matched so as to avoid Gvhd by ensuring the closest possible match.

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Lack of regulatory guidelines pegs back growth of graft versus host disease market
The disease is orphan in nature, which can be one of the important factors affecting the lack of guidelines and treatment regimes. Lack of randomized clinical trials is another factor that contributes towards non-popularity of Gvhd due to the use of variable clinical trial endpoints conducted studies till date. This has resulted in inappropriate clinical evidences, which are not comparable and not directly applicable to all Gvhd patient groups. However, advancements in the process of early detection of symptoms is projected to support growth of the graft versus host disease market in the near future.
Major research universities in the GvHD market are engaged in research and development processes to further enhance the outcomes of the therapy. For instance, research conducted by the University Of Michigan, in 2017, revised the understanding regarding the graft vs. host disease origins, which can offer new direction for potential therapy in the near future.

Key Players: Sanofi, Novartis AG, Neovii Biotech GmbH, Merck & Co., Astellas Pharma Inc., Soligenix, Inc., and Mesoblast Ltd.

Graft Versus Host Disease Market Taxonomy:
By Disease Type
• Acute graft vs. host disease (aGvHD)
• Chronic graft vs. host disease (cGvHD)
By Product Type
• Monoclonal antibodies
• mTOR inhibitors
• Tyrosine kinase inhibitors
• Thalidomide
• Etanercept

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