Etamsylate (sometimes spelt ethamsylate) is an anti-hemorrhagic drug that works by raising resistance in the capillary endothelium and enhancing platelet adhesion. It also prevents platelet disaggregation, vasodilation, and enhanced capillary permeability by inhibiting prostaglandin manufacture and activity.

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Action Mechanism:
Etamsylate is a hemostatic drug that also has proaggregant and angioprotective properties. It promotes thrombopoiesis and the release of platelets from the bone marrow. Haemostatic action is attributed to the stimulation of thromboplastin creation on injured areas of tiny blood arteries and a decrease in PgI2 (Prostacyclin I2) synthesis; it also facilitates platelet aggregation and adhesion, which, in turn, causes the haemorrhage to reduce and cease.

Etamsylate's exact method of action is uncertain. It has been proven to lessen wound bleeding time and blood loss. This appears to be linked to enhanced platelet aggregation mediated by thromboxane A2 or prostaglandin F2a. Reduced levels of 6-oxoprostaglandin F1a, a stable prostacyclin metabolite, have also been linked to it.

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Prostacyclin is a powerful vasodilator that may be involved in reperfusion, as well as a platelet disaggregator. Etamsylate was also suggested to help capillaries stay stable by polymerizing hyaluronic acid and stiffening capillary membranes. Through its impact on hyaluronic acid, etamsylate reduces capillary bleeding, and preliminary trials have shown a reduction in intraventricular haemorrhage.

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Etamsylate may affect microcirculation, vasoconstriction, and also promote platelet aggregation, which may result in haemostasis. It also reduces oedema caused by capillary leakage by inhibiting the effects of prostaglandin-mediated vasodilation and enhanced capillary permeability. Etamsylate may potentially help to avoid subsequent injury by reducing reperfusion bleeding in ischemic parts of the brain. Etamsylate may work by narrowing the patent ductus and improving cerebral blood flow by reducing the effects of prostaglandins.