Vitamin D2 is chemically named Ergocalciferol, which is a ring-opening steroid formed by the cleavage of chemical bonds of steroids under the action of photochemistry, especially through the action of ultraviolet rays and ergosterol. The ergocalciferol prepared early is also called Viosterol. According to the 2011 diagnostic guidelines in the United States, ergocalciferol may be used as a dietary supplement-to-supplement vitamin D. Ergocalciferol is equally effective as cholecalciferol (vitamin D3) produced by the skin under ultraviolet radiation. The commercial product of ergocalciferol has many names. Vitamin D2 is absorbed by the small intestine and its absorption requires bile salts combined with special α-globulin and then transported to other parts of the body, where it is stored in the liver and fat. Metabolism and activation first pass through the liver, followed by the kidneys. The onset time of action is 12 to 24 hours, and the treatment effect takes 10 to 14 days.

The Pharmacology and Toxicology

This product is a vitamin medicine. Vitamin D2 promotes the absorption of calcium by the brush border of the small intestine mucosa and the reabsorption of phosphorus in the renal tubules, increases the concentration of blood calcium and phosphorus, and cooperates with parathyroid hormone (PTH) and calcitonin (CT) to promote the release of calcium phosphate from old bones. Maintain and regulate normal plasma calcium and phosphorus concentrations. Vitamin D2 promotes calcium deposition in new bone formation sites, deposits citrate in bone, promotes bone calcification, osteoblast function and bone-like tissue maturation. After vitamin D2 is ingested, it is catalyzed by the 25-hydroxylase system to produce calcidiol (25-OHD3) in the cell microsomes, and then catalyzed by the 1-hydroxylase system of renal proximal tubule cells to produce biologically active bone Triol [1-25-(OH)2D3]. In animal experiments, after the parathyroid glands of the mice were removed, the 1-hydroxylase activity was lost and calcitriol could not be synthesized. In hypercalcemia, CT secretion increases, 1-hydroxylase activity is inhibited, and the conversion of calcidiol into calcitriol decreases. It is confirmed that calcitriol metabolism is regulated by PTH and CT, and phosphate and calcium can also regulates the activity of 1-hydroxylase.

The Indications

1. Used for the prevention and treatment of vitamin D deficiency. Such as vegans, parenteral nutrition patients, pancreatic insufficiency with malabsorption syndrome, hepatobiliary diseases (liver damage, cirrhosis, obstructive jaundice), small bowel diseases (lipid diarrhea, localized enteritis, long-term diarrhea), stomach Removal and so on.

2. Used for chronic hypocalcemia, hypophosphatemia, rickets and osteomalacia with chronic renal insufficiency, familial hypophosphatemia and hypoparathyroidism (postoperative, idiopathic or pseudo Hypoparathyroidism) treatment.

3. Used to treat acute, chronic and potential postoperative tetany and idiopathic tetany.

The Role and Functions of Vitamin D2

1. Vitamin d2 may help us effectively improve our body's absorption of calcium and phosphorus, so that the plasma calcium and plasma phosphorus levels in our body are at a relatively saturated level, thereby effectively ensuring the health and stability of various functions in our body.

2. In addition, vitamin d2 can also help us promote the growth of the body and the calcification of bones, as well as the health and integrity of teeth. Therefore, vitamin d2 has very important practical significance for the prevention and treatment of osteoporosis, which is a part we need to understand.

3. Vitamin d2 can help increase the absorption of phosphorus in the intestinal wall, and at the same time can further increase the reabsorption of phosphorus in the renal tubules.

4. Vitamin d2 has very important practical significance for maintaining the normal level of citrate in the blood. This is also one of the functions of vitamin d2 that we must not ignore.

5. Finally, vitamin d2 can also help us effectively prevent the loss of amino acids through the kidney area.
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https://www.bocsci.com/vitamin-d3-and-impurities-list-1960.html
https://www.bocsci.com/vitamin-d2-cas-50-14-6-item-84-93158.html