Continuous pressure on the blood vessels in the rectum can cause protruding piles. Pressure due to straining, constipation, pressure in advancing age, obesity, liver conditions and chronic use of laxatives can cause it. Severe pain is one of the symptoms of the condition where the history of colon rectal malignancy is examined to assess the real cause of the problem. External hemorrhoids are found in the sensitive area around the anus and if the blood clots develop, it can cause painful swelling. Bleeding occurs when the hemorrhoids ruptures and internal hemorrhoids can be very painful in condition when it protrudes and cannot be pushed back. Xanthones from the herb M. ferrea has anti-ulcer activities, as tested on laboratory animals with extensive ulceration, perforation and hemorrhage, where the animals pretreated with the herb did not develop such conditions. The plant chemicals have anti-inflammatory activities in rats and can provide safe ways to know how to get relief from hemorrhoids.

The phyto chemicals in the plant contain secondary metabolites such as triterpenoids, xanthones and phenyl coumarins which provide analgesic, anti-microbial and immune stimulant effects and it is one of the key ingredients in herbal Pilesgon capsules. Sapindus Mukorossi in the capsules provides defense system to fight pathogens and shrink piles at home. The nuts of the tree produce soapy lather and have anti-microbial activities. It has antifungal properties and can be used to prevent platelet aggregation. The property is stronger as compared to aspirin due to the presence of bio chemicals Sapindus saponins Q, R. The herb has anti-inflammatory properties where the crude saponins from the herb can cure arthritis pain.

Acacia Catechu, one of the herbs in the cure, has been used to shrink piles at home, leucorrhea and fever. It cures mucus discharge and arrests excess mucus production in the digestive tract. The bio-chemicals catechins is used to treat infections and as a hepato protective agent due to astringent properties.

Terminalia Chebula has extraordinary power to destroy diseases and eliminate waste from the body. It is effective against herpes simplex virus and can exhibit cardio tonic activities. It is rich in antioxidants and increases the life of body cells. It has rejuvenating and cleansing activities in the gastrointestinal tract. During lab tests it was found effective against bleeding piles. The test on laboratory rats showed its intake was is to activate the endothelial cells, macrophages, fibroblasts and mast cells.

The extract of leave of the plant Bryophyllum Calycinum as in Pilesgon capsules has nephro protective activities and can exert diuresis to provide easy ways to how to get relief from hemorrhoids. Its extract, as in the capsules - inhibits the development of acute ulcers in the digestive tract and the study reveals the herb can provide protection against lesions in the gastro intestinal tract induced by serotonin, stress, aspirin and reserpine. The property of healing was tested on acetic acid induced chronic gastric lesion in the test group of rats, where it could heal internal wounds due to the presence of steroid glycosides and has strong anti-inflammatory and analgesic effects.