Nucleotides are the fundamental building blocks of nucleic acids. A nucleotide comprises a sugar molecule (ribose in RNA or deoxyribose in DNA) linked to a phosphate group and a nitrogen-containing base.

Market Dynamics
The factors driving the global nucleotide market are the increasing applications of nucleotides and their further use in the future.

The increasing applications of nucleotides are expected to drive the market growth in the forecast period

Nucleotides are necessary for both nutritional and physiological functions. Palatability enhancers such as inosine monophosphate (IMP) and guanosine monophosphate (GMP) are widely used in food. This aids nucleotides in improving feed palatability. Furthermore, nucleotides influence the recovery of intestinal epithelial cells, which aids in immunity. Tissue cells involved in immunity are unable to synthesize nucleotides on their own. As a result, dietary nucleotides boost immunity. Nucleotides in food are typically found as long strands of genetic material that can contain millions of nucleotides. Nucleotides are also known as flavor enhancers and flavor improvers. Nucleotides increase sensorial acceptance through umami taste, maximize complexity, impact, continuity, and harmony of food flavors, enhance aroma performance, and allow for cost savings in formulations.

In addition to serving as nucleic acid precursors, Purine and pyrimidine nucleotides participate in a variety of metabolic functions such as energy metabolism, protein synthesis, enzyme activity regulation, and signal transduction. Nucleotides, when linked to vitamins or vitamin derivatives, form a component of many coenzymes. Nucleotides play various roles in metabolic regulation, including ATP-dependent phosphorylation of key metabolic enzymes, allosteric regulation of enzymes by ATP, ADP, AMP, and CTP, and control of the rate of oxidative phosphorylation by ADP. In hormonally regulated events, the cyclic nucleotides cAMP and cGMP act as second messengers. GTP and GDP play important roles in the cascade of events that characterize signal transduction pathways. In addition to their important roles in metabolism, nucleotides have medical applications such as synthetic purine and pyrimidine analogues containing halogens, thiols, or additional nitrogen atoms in cancer and AIDS chemotherapy and as immune suppressors during organ transplantation. Hence, with the numerous applications nucleotides provide, it is expected to drive the market in the forecast period.

The high cost of genome sequencing is expected to hamper the market growth

A cancer case's total genome sequencing cost is £6841 (£3420 per genome). Consumables account for 72% of this cost. The sequencing stage accounts for three-quarters (76%) of the costs of genome sequencing. Most of these expenses are related to using a HiSeq SBS kit, which costs £2265 per case. The HiSeq PE kit, which costs £932 per case, is also a significant cost driver. Bioinformatics and clinical interpretation are the only other stages that contribute more than 10% of the total cost of genome sequencing (12 per cent).

Global Nucleotide Market – Industry Analysis


COVID-19 Impact Analysis

COVID-19 impacted the global economy in different ways by directly affecting production and demand, causing supply chain and market disruption, and having a financial impact on firms and financial markets. Manufacturers, raw material suppliers, equipment suppliers, end users, traders, distributors affected the nucleotide market.

Segment Analysis
Gene chips & microarrays segment is expected to dominate the market

The growing demand for this technology among researchers is expected to drive market growth over the forecast period, owing to its ability to run thousands of samples simultaneously in a single experiment under nearly identical conditions. Furthermore, increasing demand in the pharmaceutical industry to screen an increasing number of molecules in smaller volumes as drug candidates are expected to drive technology growth.

Gene chips are increasingly being used in animal and plant science. Microarrays are classified into two types: cDNA and oligonucleotide. Stanford University created the cDNA microarrays, while Affymetrix created the oligonucleotide arrays. The field of genomics is rapidly expanding understanding of the disease, targets, and, in the future, how drugs may be used in the clinic. This knowledge enables better decisions to be made earlier in the therapeutic discovery and development process. Better decisions should eventually result in therapies that are more valuable and pose less risk to patients.

For instance, the GeneChip system from Affymetrix company is the industry-standard microarray solution for genomics research and development. Initially used for target identification, GeneChip RNA expression analysis products are now being used downstream by innovative biotechnology and pharmaceutical companies for target validation, lead optimization, and clinical trials. The ability to generate sensitive and specific gene expression profiles has proven critical in identifying drug targets. There are hundreds of examples of GeneChip technology being used for a molecular understanding of disease states and to identify valuable gene targets. The ability to screen large areas of the genome for informative haplotype markers and causative or diagnostic SNPs can allow researchers to identify informative haplotype markers and causative or diagnostic SNPs in the field of genotyping.

Geographical Analysis
Asia Pacific region is expected to hold the largest market share in the global nucleotide market

The presence of the world's largest nucleotide producer, combined with the demand for nutraceuticals and the health food processing industry, is expected to boost demand in this region. In addition, growing explorations of food and beverage additives, particularly in the Asia Pacific, are expected to fuel demand growth in the coming years. China is the world's second-largest pharmaceutical market. The pharmaceutical market is rapidly expanding due to the country's growing middle-class and ageing population, rising incomes, and increasing urbanization. Similarly, rising rates of lifestyle diseases, rising demand for affordable healthcare delivery systems as healthcare costs rise, technological advancements, and government initiatives such as e-health, combined with tax breaks and incentives, are propelling the country's healthcare industry. ​

Competitive Landscape
The global nucleotide market is highly competitive, with companies adopting recent technologies. Some of the key players in the market are CJ CheilJedang Corp., Thermo Fisher Scientific Inc., Daesang, Star Lake Bioscience, Meihua Group, F. Hoffmann-La Roche Ltd., Promega Corporation, Affymetrix Inc., Lallemand Inc., Nanjing BioTogether Co., Ltd.

Thermo Fisher Scientific Inc

Overview: Thermo Fisher Scientific is based in the United States that sells scientific instruments, reagents and consumables, and software services. The company's headquarters are in Waltham, Massachusetts. ​The company was founded in 1956.

Product Portfolio: Thermo Fisher Scientific is one of the industry's few primary manufacturers of nucleotides. The company's nucleotides include dNTPs, NTPs, and modified nucleotides.

Key Development: On September 20, 2021, Thermo Fisher Scientific Expanded Genetic Analysis Capabilities with Digital PCR. Thermo Fisher Scientific introduced the Applied Biosystems QuantStudio Absolute Q Digital PCR System, the first fully integrated digital PCR (dPCR) system designed to deliver highly accurate and consistent results in 90 minutes.
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