Thermoelectric coolers can be used for applications that require heat removal ranging from milli-watts up to several thousand watts. However, there is a general axiom in thermoelectrics: the smaller the better. A thermoelectric cooler makes the most sense when used in applications where even the smallest vapor compressor system would provide much more cooling than necessary. One application of Thermocyclers is in aerospace and defense technologies. Because II-VI’s Thermocycler technology can withstand extreme conditions, these modules are ideal for use in space or similar demanding conditions.

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The most commonly used material for the manufacturing of thermoelectric coolers is bismuth telluride (Be2Te3). This is because of its relatively high figure of merit. However, the performance track record of this material is still relatively poor and better-performing materials are currently used in the manufacturing of thermoelectric modules. The alternatives to Be2Te¬3¬¬ include antimony telluride (Sb2Te3), lead telluride (PbTe), and silicon–germanium. Some of these materials perform exceptionally well in high-temperature applications.

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