Immunology Drugs --Outlook on Global & Chinese Market , 2017-2022


Posted July 6, 2017 by AkaMrrs

Tends forecast: analysis of regional demand and growth trends, all the numbers, both – sales & volume, at each level of the detail are estimated till 2022, to give a glimpse of the potential market size in terms of value in this market.

 
[ Immunology Drugs --Outlook on Global & Chinese Market , 2017-2022 ]

Latest Report on Global Immunology Drugs Market in 2017 added by Market Research Report Store gives an overview which focuses on the top manufacturers/players in Global market, with sales, price, revenue and market share for each player, market segment by regions, split by product types and applications.


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Scope Of The Report:
Global Immunology Drugs Market to 2022 – Increasing Prevalence, Repositioning Opportunities and Strong Uptake of Interleukin Receptor Inhibitors to Drive Growth

Summary

Immunology is a therapy area characterized by disorders of the immune system, specifically an aberrant autoimmune response against healthy tissues in the body, leading to chronic or acute inflammation. Depending on the specific site affected, this can lead to various types of chronic pain and mobility loss, and have a negative impact on quality of life.

A number of therapies have been approved for immunological disorders, including the largely genericized disease-modifying anti-rheumatic drug (DMARD) class of small molecule drugs. However, as these therapies often fail to elicit an adequate long-term response, a large second-line therapy segment has emerged in these markets, beginning with the approval of Remicade (infliximab) and Enbrel (etanercept) in 1998. There is currently no cure for immunological disorders due to the highly complex nature of the immune system and the fact that many components of the pathophysiological states of these diseases have roles in the healthy immune system.

Autoimmune disorders are currently incurable, and treatment is aimed at managing the disease, in order to reduce the severity of its symptoms and lower the risk of associated co-morbidities. Cytokines and their receptors, such as Tumor Necrosis Factor-α and Interleukin-6 are the most effective and most common therapies used in immunology. This class of compounds has been the most commercially successful in the past decade, particularly in the RA market, with many clinical trials underway across various immunological indications. The market for immunological disorders is largely accounted for by premium products, with only a relatively small revenue share accounted for by generics and biosimilars.

Inflectra, a biosimilar of Remicade was recently approved by the FDA in 2016. However, the gradual uptake of biosimilars such as Inflectra is not expected to act as a strong growth driver for the biosimilar segment within the forecast period. This therefore means existing products such as Remicade are expected to maintain high revenues during the forecast period

Although there is a high degree of failure and uncertainty in R&D of immunological drugs, there are 2,054 drugs in active development in the immunology pipeline. In the long-term, this is expected to drive growth in this market in spite of the anticipated approval of biosimilars for key blockbuster drugs and resultant erosion of revenues. Cytokines and their receptors account for the largest single segment of each of the pipelines which make up the largest individual class.

The report focuses on four key indications within immunology: Rheumatoid arthritis, Systemic lupus erythematosus (SLE), Psoriasis and Inflammatory bowel disease (The two major types of Inflammatory bowel disease covered in this report are Ulcerative colitis and Crohn’s disease). With no curative therapies available, symptomatic medications prescribed off-label are an important part of the treatment paradigm, especially in SLE, increasing the need for extensive R&D within this area.

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The Parts From Contents
1 Table of Contents
1 Table of Contents 4
1.1 List of Tables 6
1.2 List of Figures 6
2 Introduction 9
2.1 Therapy Area Introduction 9
2.1.1 Rheumatoid Arthritis 9
2.1.2 Systemic Lupus Erythematosus 10
2.1.3 Psoriasis 11
2.1.4 Inflammatory Bowel Disease 12
2.2 Symptoms 13
2.3 Etiology and Pathophysiology 15
2.3.1 Pathophysiology 17
2.4 Epidemiology 21
2.4.1 Rheumatoid Arthritis 22
2.4.2 Systemic Lupus Erythematosus 23
2.4.3 Psoriasis 23
2.4.4 Inflammatory Bowel Disease 24
2.5 Co-morbidities and Complications 25
2.6 Treatment 26
2.6.1 Rheumatoid Arthritis 27
2.6.2 Systemic Lupus Erythematosus 30
2.6.3 Psoriasis 31
2.6.4 Inflammatory Bowel Disease 32
3 Key Marketed Products 34
3.1 Overview 34
3.2 Humira (adalimumab) 34
3.3 Enbrel (etanercept) 36
3.4 Remicade (infliximab) 38
3.5 Rituxan (rituximab) 40
3.6 Stelara (ustekinumab) 42
3.7 Simponi (golimumab) 43
3.8 Prograf (tacrolimus) 45
3.9 Cimzia (certolizumab pegol) 46
3.10 Entyvio (vedolizumab) 47
3.11 Cosentyx (Secukinumab) 49
4 Pipeline Landscape Assessment 51
4.1 Overview 51
4.2 Pipeline Development Landscape 51
4.3 Molecular Targets in the Pipeline 54
4.4 Clinical Trials 56
4.4.1 Failure Rate by Stage of Development, Indication, Molecule Type and Molecular Target 56
4.4.2 Clinical Trial Duration by Stage of Development, Indication, Molecule Type and Molecular Target 60
4.4.3 Clinical Trial Size 65
4.4.4 Aggregate Clinical Program Size 69
4.4.5 Assessment of Key Pipeline Products 72
4.5 Conclusion 80

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Last Updated July 6, 2017