Biomaterials have gained tremendous attention in tissue engineering and regenerative medicine applications attributing to their ability to enhance functional tissue regeneration. Biomaterial can be categories into natural biomaterials and synthetic biomaterials. Natural biomaterials offer various advantages over synthetic biomaterials such as they already have binding sites for cells and adhesion molecules so the biocompatibility is not a major issue. On account of advantages offered, the demand for natural biomaterials is projected to upsurge over the forecast period.

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The market is projected to reach US$ 194.29 billion by the end of 2027, growing substantially over the forecast period, owing to rising prevalence of conditions such as osteoarthritis, rheumatoid arthritis, and sports injuries. Moreover, factors such as rising prevalence of cardiovascular diseases, increasing demand for plastics surgeries, growing cancer incidence are playing major role in fueling growth of the natural biomaterials market.
Naturally derived biomaterials is classified into many groups including polysaccharide-based biomaterials (chitin/chitosan, cellulose, glucose, etc.), protein-based biomaterials (gelatin, collagen, silk, etc.), and de-cellularized tissue-derived biomaterials (blood vessels, liver, heart valves, etc.). Natural biomaterials are preferred over synthetic biomaterials for restoring or replacing structure and for functioning of damaged tissues or organs attributing to their ability to support migration, cell adhesion, differentiation, and proliferation. The three main applications of natural biomaterials in medical are drug delivery system, tissue engineering, and wound management applications.

On the basis of product type, the natural biomaterials industry is segmented into hyaluronic acid collagen, gelatin, fibrin, cellulose, chitin/chitosan, alginate, and silk. Collagen is the most frequently used natural biomaterial and thus more studied biomaterial. Collagen is rich in vivo sources, as all connective tissues of animals are rich in ubiquitous protein. Moreover, collagen has fibrous structure and its amino acid composition is unique. It has superior biocompatibility, being a conserved protein. Collagen offers additional benefits such as capability of supporting a large spectrum cellular differentiation type, thus boosting the demand for collagen segment in the near future. Stringent rules and regulations in the field of medical reforms in the healthcare industry are expected to hinder growth of biomaterials market.

The global natural biomaterials market accounted for US$ 57.75 billion in 2018, and is expected to register a CAGR of 14.4% in terms of revenue, over the forecast period (2019 – 2027).

North America is anticipated to account for the largest revenue share in the global natural biomaterials market. Rising bio-based research, high healthcare expenditure, increasing conferences of biomaterials, developed healthcare infrastructure, and rising prevalence of cardiovascular diseases are expected to propel demand for natural biomaterials over the forecast period.

Furthermore, Asia Pacific is expected to witness fastest growth over the forecast period, owing to increasing demand for natural biomaterials from wound healing applications. Rising number of plastic surgeries especially in China and India is expected to propel demand for natural biomaterials in the near future.
Based on the application, cardiovascular segment held the largest market share in the global natural biomaterials industry and contributed for more than 35.0% of revenue share in 2018. The cardiovascular applications of natural biomaterials include in stents, sensors, guide wires, pacemakers, vascular grafts, and implantable cardiac defibrillators. Increasing demand for natural biomaterials from up surging orthopedic and cardiovascular surgeries such as Coronary artery bypass graft (CABG) surgery, Aortic valve surgery, Arrhythmia surgery, Congenital heart surgery, and heart transplant is expected to generate higher revenues for natural biomaterial market.

Other applications of natural biomaterials include utilization in the fabrication of tissue engineering matrices and drug delivery system. Rising geriatric population, advancements in medicinal innovations, growing government interest in research and development in the field of natural biomaterials are anticipated to drive growth of the market over the forecast period.

Players operating in the global natural biomaterials market are adopting various growth strategies such as mergers & acquisitions and business expansion to cater increasing demand for natural biomaterials. For instance, in Feb 2016, Invibio Knee Ltd., a subsidiary of Invibio Biomaterial Solutions partnered with Maxx Orthopedics Inc. to develop PEEK-OPTIMA femoral knee replacement. This technology was launched in order to meet unmet needs of patients with the outcomes of total knee arthroplasty using metal-based knee solutions.

Major players operating in the global natural biomaterials market include BASF SE, Biomet, Inc., Invibio Ltd., Mimetis Biomaterials, Royal DSM, Corbion N.V., Botiss Biomaterials GmbH, and Medtronic, Inc.

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