Bio adhesives are naturally present polymeric material and possess adhesive properties. Synthetic bio adhesives are also available in the market and have different applications such as protections of tissues, to promote wound healing, replacement for surgical sutures, and as a replacement for conventional drug delivery systems. Bio adhesives are biocompatible products, and hence are often used in biological applications and mainly in surgeries as sealants. Manufacturers such as Cryolife, Baxter International Inc., Luna Innovations Incorporated, B. Braun Melsungen AG, Johnson and Johnson and others offer products in this market. For instance, in December 2019, CryoLife, Inc. partnered with Misonix for commercialization of CryoLife's NeoPatch product for the treatment of various indications outside of cardiac and vascular surgery.
Tissue glue is used as an alternative method for wound closure that is painless, fast, and does not require a follow-up visit for removal. Tissue glue is made from cyanoacrylate compounds. Tissue glue finds application in superficial lacerations, low wound tension, and after placement of deep sutures to close skin.
Bio-adhesive sealants are developed from proteins, collagen, thrombin, fibrin, gelatin, and polysaccharides such as chitosan are used for acute thoracic aortic dissection repair, controlling intraoperative bleeding in vascular procedures, and for soft tissue sealing.
The global tissue glue and bio-adhesive sealants market is estimated to account for US$ 1,509.6 Mn in terms of value in 2019 is expected to reach US$ 2,876.9 Mn by the end of 2027.
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Global Tissue Glue and Bio-adhesive Sealants Market: Drivers
Increasing prevalence of bone-related disorders is expected to propel growth of the global tissue glue and bio-adhesive sealants market over the forecast period. For instance, according to the paper ‘New Osteoporotic/Vertebral Compression Fractures’, published in 2018 by National Center for Biotechnology Information (NCBI), the U.S. records 700,000 cases of vertebral compression fractures, annually.
Increasing number of arthroplasty procedures is also expected to aid in growth of the market. For instance, in 2018, the American Academy of Orthopaedic Surgeons (AAOS) and the American Joint Replacement Registry (AJRR) recorded over 1 million patients and over 1.4 million hip and knee arthroplasty procedures.
North America region held dominant position in the global tissue glue and bio-adhesive sealants market in 2018, accounting for 51.5% share in terms of value, followed by Europe.
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Global Tissue Glue and Bio-adhesive Sealants Market: Restraints
There are several complications in cemented arthroplasty such as inflammation of surrounding soft tissue and breakdown of cement, which may prompt the need for second arthroplasty surgery. Such risks decrease the demand for cemented arthroplasty, which in turn restrains growth of the global tissue glue and bio-adhesive sealants market to a certain extent.
Moreover, lack of adoption of tissue glue and bio-adhesive sealants in emerging economies is also expected to hamper growth of the market. This can be attributed to lack of awareness regarding the benefits, clinical efficacy, safety, and cost-effectiveness of tissue glue and bio-adhesive sealants compared to substitute products or procedures and tissue repair therapies.
Global Tissue Glue and Bio-adhesive Sealants Market: Opportunities
Increasing number of surgeries and amputations is expected to offer lucrative growth opportunities for players in the global tissue glue and bio-adhesive sealants market. For instance, according to the study, ‘Estimating the Prevalence of Limb Loss in the United States: 2005 to 2050", published in the Archives of Physical Medicine and Rehabilitation, there will be an estimated 3.6 million people in the U.S. living with limb loss by 2050.
Moreover, increasing R&D in tissue glue and bio-adhesive sealants is also expected to aid in growth of the market. For instance, in December 2018, researchers from Uppsala University and Stockholm University reported development of new class of bioinspired calcium phosphate cements that can glue tissues together and bond tissues to metallic and polymeric biomaterials.

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