Advanced cancer usually bypass the anticancer drug roadblock set continues to grow rapidly, recently, the internationally renowned Journal of the National Academy of Sciences was published in PNAS Online from United States Purdue University researchers ' latest findings "Sensitive Kinase Assay linked with phosphoproteomics for identifying direct kinase substrates,", article, Researchers mapped the Atlas of kinase target protein interactions with them, to help found the pharmaceutical shortcuts, develop more effective anticancer drugs.

Protein kinase phosphate group attached to your destination on the amino acid residues of proteins, protein-specific sites of phosphorylation process known as phosphorylation. Through this mechanism can be turned on or off certain functions of the cell. Phosphorylation disorders can cause cells to grow out of control, is a sign of cancer.

Many effective cancer drugs are kinase inhibitors, they block kinase combined with specific proteins within cells, preventing phosphorylation and cancer cells.

United States Purdue University Biochemistry Professor of analytical chemistry, Member of the cancer research center w. Andy Tao (W. Andy Tao) is the leader of the study. Tao Weiguo think the terminal illness, invalid reason is because kinase kinase inhibitors have been adjusted, found a new target proteins, forming a new cancer cells. He believes that make cancer cells all potential route map is a key part of developing better cancer treatments.

"I'm trying to say is, 99% kinase inhibitors are valid only on advanced cancer for months at a time, followed by cancers to form tolerance. In the beginning, and unable to adjust themselves so that the death of the cell. Later, cancer cells have found a way of survival. You block one way, and they find another way, "w. Andy Tao said.

Building Atlas of protein kinase-Tao Weiguo identification they direct protein phosphorylation and kinase targets, and excluding other indirect targeting of proteins. Which would normally have been directly targeted protein phosphorylation cascade initiated by phosphorylation.

W. Andy Tao kinase compares the cell-free, confirmed only when the kinase is present, phosphorus and protein can be thought of as potential targets. First of all, he makes these phosphoprotein phosphorylation. Then reimport kinase, which accepts the phosphate group from the kinase protein that their direct target. W. Andy Tao said that information, pharmaceutical companies can reach all potential targets developed block kinase kinase inhibitor, making the drug more effective.

"If you're familiar with the network, you can block all the way to a cure for cancer," w. Andy Tao said.

Current research focus of w. Andy Tao SYK kinase associated with leukemia and breast cancer. He plans to further explore other mutation of kinases and kinase, to see whether they have different protein targets.