Molecular cytogenetics refers to the study of chromosomal structures with use of molecular techniques. The technique provides a combination of both molecular and cytological approach to research and diagnosis. Molecular cytogenetics is being considered as an indispensable tool for the diagnosis and research of numerous chromosomal aberrations. The technique is preferred over traditional chromosomal banding technique as traditional techniques provide low resolution level and may escape detection of copy number variations.

The breakthrough in the molecular cytogenetics technologies such FISH and aCGH are providing new dimensions to the areas of research and molecular diagnostics. These techniques are considered as invaluable tool for gene mapping, gene discovery and complex disease trait analysis. Molecular cytogenetics facilitates diagnosis and prognosis of diseases associated with hematological malignancies and solid tumors at molecular level. Likewise, alongwith diagnosis and prognosis of tumors, the technique is facilitating the practice of personalized medicines. The global molecular cytogenetics market was valued at USD 469.2 million in 2012 and is expected to grow at a CAGR of 23.4% from 2013 to 2019 to reach at an estimated value of USD 1.9 billion in 2019.

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Currently, aCGH technique is gaining momentum as compared to FISH technique owing to higher resolution over other traditional banding techniques. Earlier, where cytogenetics field was limited to identification of chromosome structure, it has now expanded its horizons to assessment of structural and functional genetic anomalies. FISH characterized by its ability to interpret information at genome level currently, captures the lion’s share of the molecular cytogenetics market. The technique has been utilized over the past decade for identification of various diseases and in suggesting accurate treatment options to the physicians. The technique is known for its accuracy, speed, sensitivity and high resolution over the traditional methods. Further, owing to its growing importance in laboratories the technique is backed by technological advancements such as improved fluroscence microscopes and digital imaging. Moreover, the technique is also supported by ongoing developments in the field of genomics and bioinformatics. FISH has become an essential tool for the validation of diseases and is being extensively used in laboratories and hospitals.

As stated in the report, the rising occurrence of cancer globally and the introduction of advanced and modern technologies for molecular cytogenesis have propelled the growth of the market. On the other hand, the absence of transparency and widespread availability of medical reimbursement policies may impede the growth of the market in the coming years.

On the basis of technology, the report segments the market for molecular cytogenetics into array-comparative genomic hybridization (aCGH) and fluorescence in situ hybridization (FISH). Amongst these, the aCGH technique has gained more demand than the FISH technique due to its high-resolution results and accurate analysis as compared to other conventional banding techniques. This segment is predicted to rise at a CAGR of over 20% from 2013 to 2019 and is poised to dominate the market on the basis of demand.

On the other hand, the segment of FISH also holds a dominant share in the market; the technology has been utilized since the past many years for identifying numerous diseases and for suggesting suitable treatment options. In addition, this technique is also backed by the ongoing advancements within the field of bioinformatics and genomics. FISH has emerged as a key tool for disease validation and thus is increasingly utilized in hospitals and laboratories. By application, the report segments the market into cancer, genetic disorders, personalized medicines, and others including infectious, cardiovascular, and neurological diseases.

By geography, the report segments the molecular cytogenetics market into Asia Pacific, North America, Europe, and Rest of the World (RoW). Amongst these, the North America molecular cytogenetics market held the largest share in 2012 and was trailed by Europe. The growth of the market in these two regions is fuelled by factors such as the increasing awareness amongst people about molecular cytogenetics and the growing count of research laboratories within these regions. In addition, the advancement of personalized medicines and the increasing occurrence of cancer in these two regions will also augment the growth of the market here. On the other hand, Asia Pacific is predicted to emerge as the most swiftly developing market in the forecast horizon due to the increasing population base within this region.

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The molecular cytogenetics market has grown from $469.2 million in 2012 to an estimated $1.9 billion in 2019 due to the success of techniques such as fluorescence in situ hybridization (FISH) and array comparative genomic hybridization (aCGH). The research report scrutinizes the global market and provides a quantitative and qualitative analysis on the various segments.

The global molecular cytogenetics market, expected to grow at 23.4% CAGR from 2013-2019, has provided a breakthrough in the fields of research and molecular diagnostics. Earlier restricted to merely identifying chromosome structure, the area of cytogenetics has expanded to assessing structural and functional genetic anomalies. The aCGH technique is currently growing at a CAGR of over 20% compared to FISH technique and is predicted to dominate the market in the forecast period. The main reasons for its rising demand are high resolution, accurate analysis, rapid results and the ability to perform thousands of experiments in a single array, hence saving time and cost.

According to the report, the prime players operating in the market for molecular cytogenetics are Abbott Laboratories, Agilent Technologies, Inc., Oxford Gene Technology, Illumina, Inc., and Bio-Rad Laboratories, among others.

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