The clinical management of agitation associated with schizophrenia or bipolar mania includes behavioral and psychological techniques, as well as the use of nonspecific sedating agents such as benzodiazepines and/or antipsychotics that also at the same time would be expected to treat the underlying psychiatric condition. Goals of treatment of Agitation Equipment include calming the patient as rapidly as possible, decreasing the likelihood of harm to self or others, allowing diagnostic tests or procedures to take place, attenuating psychosis, and decreasing the need for seclusion or restraint (a time of high risk for patients and staff injury). Sleep, in itself, is not desirable when evaluating the patient; excessive sedation results in the need for constant observation, assistance in toileting, and excessive burdens being placed on nursing staff resources.

A production mixing unit is usually not geometrically similar to the mixer used for process development. Such differences can make scale-up from the laboratory or pilot plant challenging. A solution to these problems is to systematically calculate and evaluate mixing characteristics for each geometry change. Geometric similarity is often used in mixing scale-up because it greatly simplifies design calculations.

Geometric similarity means that a single ratio between small scale and large scale applies to every length dimension. With geometric similarity, all of the length dimensions in the large-scale equipment are set by the corresponding dimensions in the small-scale equipment. The only remaining variable for scale-up to large-scale mixing is the rotational speed-one or more mixing characteristics, such as tip speed, can be duplicated by the appropriate selection of a large-scale mixer speed.

Thickening Equipment is a method of removing a slurry having shear-thinning visco-plastic properties from a reservoir holding a body of the slurry, the slurry having a viscosity so high that direct withdrawal of a flow of the slurry from the reservoir is difficult, the method comprising: creating a submerged region of shear-thinned slurry of reduced viscosityin the body of slurry for entraining adjacent slurry of the high viscosity; and removing from the reservoir a portion of the slurry of reduced viscosity containing entrained slurry of high viscosity. The stream of shear-thinned slurry is preferably created by withdrawing slurry temporarily from the submerged region via an outlet to form a flow of withdrawn slurry, subjecting the withdrawn slurry to shear to produce a flow of shear-thinned slurry of reduced viscosity, and returning the shear-thinned slurry of reduced viscosity to the submerged region of the body via an inlet spaced from the outlet, thereby creating a flow of slurry between the inlet and the outlet. This withdrawal, shear application and return is preferably carried out continuously, at least during the period when slurry is to be transferred from the reservoir.

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