Founded in 2004 by a group of experts who devote themselves to a wide scope of diseases’ treatment, Creative Biolabs convinces that the establishment of a custom-service-centered business model will become the key to optimizing the drug discovery and development process, leveraging available resources and gathering a team with profound experience to conduct drug discovery projects in the future. As one of the few companies who is able to provide integrated drug discovery services for clients all over the world, experienced and knowledgeable scientists are making concerted efforts to realize the optimization of clients’ projects with services ranging from target identification and validation, hit identification, hit to lead, lead optimization to the investigational new drug (IND), and are subdivided into numerous details. Services not only cover the entire discovery pipeline but also are able to cater to specific requirements.

Creative Biolabs has developed IVD Antibody Development Platform to improve a wide range of customized research and development services, including IVD Antibody Development, Antibody & Protein Conjugation, IVD Kit Development, etc. Specifically speaking, the IVD antibody development services possess the capability to develop a wide scope of antibody species like monoclonal antibodies, polyclonal antibodies, antibody pair, recombinant antibodies against cancer, autoimmune diseases, infectious diseases, and cardiovascular diseases.

1. With the help of advanced IVD antibody discovery platform, monoclonal antibody development services that meet every standard are ready for in vitro research and diagnostic assays, which principally benefit from the development of hybridoma for monoclonal antibodies with high specificity. The monoclonal antibodies (hamster, rat, sheep monoclonal antibodies and chicken IgY antibodies) developed under Creative Biolabs’ assistance can be extensively applied in the field of diagnostics, therapeutics of a variety of disease, not just for bacteria, viruses or protozoa caused infectious diseases, but also for cancer, autoimmune diseases and hormonal disorders. Besides, such designed monoclonal antibodies can be applied in the diagnosis of lymphoid and myeloid malignancies, tissue typing, enzyme-linked immunosorbent assay, radio immunoassay, serotyping of microorganisms.

2. Polyclonal antibodies (pAb) are offered to be adopted in the in vitro assays in many different formats ranging from sophisticated flow cytometry (FCM) to simple enzyme-linked immunosorbent assay (ELISA), of which the results are commonly used to support a tentative clinical diagnosis, to evaluate disease progression, and to provide prognostic information. Creative Biolabs serves qualified and well designed polyclonal antibodies for IVD use to meet the laboratory research standard and even further serve the clinical market.

3. As for the custom antibody development services, optional display platforms are equipped: phage display, ribosome display, yeast display, etc. Key services accordingly consist:

l Antibody affinity maturation is the process to enhance antibody affinity for antigens both in vivo and in vitro.

l Recombinant antibody reformatting is for getting soluble antibody fragments or full monoclonal antibodies from the antigen binding regions of an antibody.

l Recombinant antibody switching helps to realize free changes in subtypes, species, isotype.

4. Antibody drug conjugates in cancer therapy required can be realized with the help of antigen and antibody conjugation services of various types, which can sharply cut the expenses and time cost of projects, including

Protein-protein Conjugation

Particle Conjugation

Oligonucleotide Conjugation

Biotin Labeling

Fluorescent Dyes Labeling

Special Labeling: Europium, Ruthenium

Creative Biolabs has years of experience in this field by providing an enormous scope of antibody development services and recombinant antibody products from different hosts. IVD antibodies have a place in many diagnostic tests, which function as detecting infections, allergies, the measurement of hormones, and other markers in the blood. Through over years’ hard working and development, professional Doctor level research teams, a full set of up-to-date technique platforms make it become one of the well-recognized service providers all over the world. Meanwhile, Creative Biolabs has demonstrated the reliable expertise and capability in biotech/pharmaceutical market and expanded the custom services to the full pipeline of drug discovery and development industries with a group of experts pleased to facilitate the drug R&D projects of clients by providing the most comprehensive services from early discovery to clinical trials.