An overview of experiments with nonhuman primates

Posted August 7, 2019 by Bonnibelle

Non-human primates (NHPs) are the closest relatives of human beings. Their organizational structure and physiological functions are similar to humans.

Non-human primates (NHPs) are the closest relatives of human beings. Their organizational structure and physiological functions are similar to humans. They are ideal animal models (model monkeys) for preclinical experiments in human reproductive, reproductive health, life medicine, and new drug research. Non-human primates can be divided into 12 families and 57 genera according to their morphological characteristics.

Because morphology, physiology, and biochemical metabolism of NHPs are similar to humans, and they are strong, the size is appropriate, and easy to raise, they have long been used as an ideal experimental animal for various fields. And small primates such as Marmosets have been artificially bred and used in medical research.

Non-human primates, including macaques, share a high degree of homology with human genetic material, showing many similar biological and behavioral characteristics, which make them ideal animal models (model monkeys) to address basic and preclinical studies about health and disease issues. As a high-grade experimental animal, experimental monkeys are widely used in human sciences. They are important test subject in research on infectious diseases, parasitic diseases, cytology, radiobiology, immunology, pharmacology, neurobiology, and experimental surgery.

As experimental animals, experimental monkeys could be kinds of human disease models, especially in the study of AIDS, cancer, measles, hepatitis and other infectious diseases. Monkeys are very important or unique experimental animals and are irreplaceable by other species of animals. Especially in the field of medical biology, experimental monkey models are used frequently.

Therefore, the application of non-human primates (NHPs) as experimental materials is of great significance in scientific research, and its value is unmatched by other animals.

Application in medicine

Physiological research
They can be used for studies on brain function, blood circulation, blood type, respiratory physiology, endocrine, reproductive physiology, neurophysiology, behavior and gerontology.

Other disease research
Rhesus macaques can be used to replicate atherosclerosis models, chronic bronchitis models, and so on.

Infectious disease research and vaccine trials
Non-human primates are susceptible animals of certain human infectious diseases, such as hepatitis virus, poliovirus, measles virus, HIV, dysentery bacillus, and Mycobacterium tuberculosis. They are good animal models in studies of enterobacteriosis and tuberculosis. Macaques are the only experimental animals in the manufacture and identification of polio vaccines. Primates can be used for human Plasmodium infection to study Plasmodium falciparum, P. vivax, and Plasmodium vivax.

Reproductive physiology research
They are ideal experimental animals for human contraceptive research.

Behavioral and Psychiatric and Neurobiology Studies
Anti-shock paralysis drugs can be screened using animal models of monkey. The dependence of monkeys on sedatives is close to that of humans. The symptoms of withdrawal are more obvious and easier to observe. New sedatives should be tested with monkeys before entering the clinic.

With integrated NHP resources and professional pre-clinical research team, Creative Biolabs supports laboratory NHP preclinical studies by providing a large variety of NHP biological products, including but are not limited to whole blood, serum, plasma, primary cells, tissue, body fluid and recombinant reagent. In addition, as served as a contract research organization (CRO) specializing in preclinical animal studies for decades, Creative Biolabs has developed a broad range of NHP disease models (the species cover Cynomolgus Monkey, Rhesus Monkey, African Green Monkey, Baboon Cebus, Chimpanzee, Squirrel Monkey and Marmoset), which giving us capabilities in providing biologicals derived from diseased primates.
-- END ---
Share Facebook Twitter
Print Friendly and PDF DisclaimerReport Abuse
Contact Email [email protected]
Issued By
Country United States
Categories Biotech
Last Updated August 7, 2019